[Cardiovascular risk factors and metabolic syndrome associated with subclinical renal failure].
[Cardiovascular risk factors and metabolic syndrome associated with subclinical renal failure].
复制标题
[心血管危险因素和与亚临床肾衰竭相关的代谢综合征]。
DOI：
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
E. Alegrı́a
中科院分区：
文献类型：
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作者：
A. Cordero;M. Laclaustra;Montserrat León;J. Casasnovas;A. Grima;Mónica Nájar;E. Luengo;A. del Río;I. Ferreira;E. Alegrı́a
背景与目的
本研究的目的是描述亚临床肾功能不全的患病率，评估肾小球滤过率（GFR），并确定相关的心血管危险因素在活跃的工作主题的西班牙。
受试者和方法
数据收集在11,582活跃的健康工人（78.5%男性），平均年龄（标准差）40.2（10.7）岁，在他们的年度健康检查。通过3种方法估计的GFR评估肾功能：肾脏疾病饮食改良（MDRD）研究的简化方程、Cockroft-Gault（CG）方程和体重/肌酐比值。根据改良的成人治疗组III标准进行代谢综合征评估。
结果
用于估计GFR的3个方程显示不同的值。CG方法的GFR平均值最高（99.0 [25.0]）ml/min/1.73 m2，其次是MDRD和体重/肌酐比值的结果（分别为90.2 [18.5] ml/min/1.73 m2和81.2 [18.3] ml/min/1.73 m2）。轻度肾功能不全（GFR：60-89 ml/min/1.73 m2）的患病率范围为35.7%至50.8%，具体取决于所采用的方法，中度至重度（GFR < 60 ml/min/1.73 m2）的患病率范围为1.2%至2.6%。所有心血管风险因素在最差肾功能类别中更普遍。多元回归分析显示，高胆固醇血症（OR = 1.2）、代谢综合征（OR = 1.2）、超重（OR = 1.2）和高胆固醇血症（OR = 1.5）与轻度肾功能不全独立相关。高胆固醇血症（OR = 1.6）、高血压（OR = 1.6）、低HDL（OR = 2.4）和糖尿病（OR = 3.2）与中重度肾功能不全相关。
结论
亚临床肾功能不全非常普遍，并且与经典心血管危险因素和代谢综合征独立相关。
BACKGROUND AND OBJECTIVE
The objectives of this study were to describe the prevalence of subclinical renal dysfunction, assessed by glomerular filtration rate (GFR), and identify the associated cardiovascular risk factors in active working subjects of Spain.
SUBJECTS AND METHOD
Data were collected in 11,582 active healthy workers (78.5% males), mean age (standard deviation) 40.2 (10.7) years, in their annual health examinations. Renal function was assessed by the GFR estimated by 3 methods: the abbreviated equation of Modification of Diet in Renal Disease (MDRD) study, the Cockroft-Gault (CG) equation and the weight/creatinine ratio. The assessment of the metabolic syndrome was done according to the modified Adult Treatment Panel III criteria.
RESULTS
The 3 equations used for the estimation of GFR showed different values. GFR mean values were highest with the CG method (99.0 [25.0]) ml/min/1.73 m2, followed by the results of the MDRD and weigh/creatinine ratio (90.2 [18.5] ml/min/1.73 m2 and 81.2 [18.3] ml/min/1.73 m2, respectively). The prevalence of mild renal dysfunction (GFR: 60-89 ml/min/1.73 m2) ranged between 35.7% and 50.8% depending on the method applied, and the presence of moderate-severe (GFR < 60 ml/min/1.73 m2) ranged between 1.2% and 2.6%. All cardiovascular risk factors were more prevalent in the categories of worst renal function. Multivariant regression analysis showed that hypertriglyceridemia (odds ratio [OR] = 1.2), metabolic syndrome (OR = 1.2), overweight (OR = 1.2) and hypercholesterolemia (OR = 1.5) were associated independently with mild renal dysfunction. Hypercholesterolemia (OR = 1.6), hypertension (OR = 1.6), low HDL (OR = 2.4), and diabetes mellitus (OR = 3.2) were associated with moderate-severe renal dysfunction.
CONCLUSIONS
Renal subclinical dysfunction is highly prevalent and is independently associated with classical cardiovascular risk factors and metabolic syndrome.