Relationship between body mass index and the risk of ovarian cancer in the Japanese population: Findings from the Japanese Collaborate Cohort (JACC) study
Relationship between body mass index and the risk of ovarian cancer in the Japanese population: Findings from the Japanese Collaborate Cohort (JACC) study
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DOI：
10.1111/j.1447-0756.2005.00319.x
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发表时间：
2005-01-01
影响因子：
1.6
通讯作者：
Tamakoshi, A
中科院分区：
文献类型：
--
作者：
Niwa, Y;Yatsuya, H;Tamakoshi, A
目的：自20世纪70年代以来，日本卵巢癌的发病率有所上升。许多评估身体质量指数（BMI）与卵巢癌风险之间关系的研究得出了相互矛盾的结果。在这里，我们使用1988年开始的日本癌症风险评估合作队列研究的数据来调查这种关系。方法：对36456名日本女性进行问卷调查，问卷内容包括饮食习惯和其他癌症危险因素。经过7.6年的随访，有38例卵巢癌病例可供分析。Cox比例风险模型用于计算相对风险并对混杂因素进行调整。结果：与BMI为18.5-24.9 kg/m(2)的女性相比，BMI为25.0-29.9的女性患卵巢癌的相对风险为2.24 (95% CI = 1.10-4.21)， BMI为>= 30 kg/m(2)的女性患卵巢癌的相对风险为1.78 （95% CI = 0.24-13.34）。趋势检验显示，这一发现具有统计学意义（P = 0.014）。结论：这项研究的结果表明，在日本人群中，超重与患卵巢癌的高风险独立相关。
Aim: The incidence of ovarian cancer in Japan has increased since the 1970s. The many studies that have assessed the relationship between body mass index (BMI) and the risk of ovarian cancer have produced contradictory results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk, which was initiated in 1988.Methods: A self-administered questionnaire on dietary habits and other risk factors for cancer was completed by 36 456 Japanese women. After 7.6 years of follow up, 38 cases of ovarian cancer were available for analysis. Cox proportional-hazards models were used to compute relative risks and to adjust for confounders.Results: Compared to women with BMI of 18.5-24.9 kg/m(2), the relative risk of ovarian cancer was 2.24 (95% CI = 1.10-4.21) for BMI of 25.0-29.9 and 1.78 (95% CI = 0.24-13.34) for BMI of >= 30 kg/m(2). A test for trend revealed that this finding was statistically significant (P = 0.014).Conclusion: The results of this study suggest that being overweight is independently associated with a higher risk of developing ovarian cancer in the Japanese population.