Low-dose follicular-phase cocaine administration disrupts menstrual and ovarian cyclicity in rhesus monkeys.
Low-dose follicular-phase cocaine administration disrupts menstrual and ovarian cyclicity in rhesus monkeys.
复制标题
低剂量卵泡期可卡因给药会扰乱恒河猴的月经和卵巢周期。
DOI：
10.1016/s1071-5576(98)00054-9
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Schenken,RS
中科院分区：
文献类型：
--
作者：
Potter,DA;Luther,MF;Eddy,CA;Siler-Khodr,TM;King,TS;Schenken,RS
ObjectiveTO evaluate the effects of daily low-dose follicular-phase cocaine administration on menstrual cyclicity, ovulation rates, corpus luteum function, and hormone levels in rhesus monkeys.MethodNormally cycling, drug-naive, adult rhesus monkeys were randomized to receive either 1 mg/kg of cocaine (n=7), 2 mg/kg of cocaine (n = 7), or normal saline (n = 7) daily on cycle days 2 to 14. Daily blood samples were obtained through indwelling catheters for measurement of serum gonadotropins and ovarian steroids. Daily vaginal swabs were obtained to determine onset of menses. Laparoscopy was peformed 2 days after the midcycle estrogen peak to document ovulation. Daily caloric intakes as well as pretreatment and posttreatment weights were recorded.ResultsTWO of seven monkeys receiving 1 mg/kg per day and two of seven monkeys receiving 2 mg/kg per day of cocaine had timely ovulation and normal menstrual cycle lengths. One monkey receiving the 2-mg/kg dose ovulated on cycle day 24 and had a short luteal phase (7 days) with a mean progesterone level of 2.4 ng/mL. All seven saline-treated control monkeys ovulated normally; the mean cycle length was 29 days and all had adequate luteal phases. The difference in ovulation rates between cocaine-treated and control monkeys was statistically significant (P = .003). There were no differences in basal levels of LH or FSH between treatment groups. There were no significant differences in weight change or caloric intake among groups. One third of the subsequent menstrual cycles in cocaine-treated monkeys were of abnormal duration.ConclusionDaily low-dose follicular-phase cocaine administration disrupts menstrual cyclicity and folliculogenesis. This effect is independent of weight loss, caloric intake, and basal gonadotropin levels. Cocaine exposure may have a persistent effect on menstrual and ovarian cyclicity in some monkeys.
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可卡因对大鼠动情周期的慢性破坏：剂量依赖性效应。
DOI：
--
发表时间：
1993
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
King,TS;Canez,MS;Gaskill,S;Javors,MA;Schenken,RS
通讯作者：
Schenken,RS
气候控制住房对恒河猴生殖潜力的影响。
DOI：
10.1530/jrf.0.0590015
发表时间：
1980
期刊：
Journal of reproduction and fertility
影响因子：
--
作者：
D. A. Barsotti;L. Abrahamson;R. Marlar;J. Allen
通讯作者：
J. Allen
卵泡期可卡因给药对恒河猴月经和卵巢周期的影响。
影响因子：
9.8
作者：
Potter,DA;Moreno,A;Luther,MF;Eddy,CA;Siler-Khodr,TM;King,TS;Schenken,RS
通讯作者：
Schenken,RS
DOI：
10.1016/0002-9378(78)90264-8
发表时间：
1978-01-01
影响因子：
9.8
作者：
PAUERSTEIN, CJ;EDDY, CA;CROXATTO, HB
通讯作者：
CROXATTO, HB
使用抗人 FSH 血清和大鼠 FSH131I 对恒河猴中的卵泡刺激素进行放射免疫测定。
影响因子：
4.8
作者：
G. Boorman;G. Niswender;V. Gay;L. Reichert;A. Midgley
通讯作者：
A. Midgley