High prevalence and correlates of human herpesvirus-6A in nevocytic nevus and seborrheic diseases: Implication from a pilot study of skin patient tissues in Shanghai
High prevalence and correlates of human herpesvirus-6A in nevocytic nevus and seborrheic diseases: Implication from a pilot study of skin patient tissues in Shanghai
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人类疱疹病毒 6A 在痣细胞痣和脂溢性疾病中的高患病率及其相关性：上海皮肤患者组织试点研究的启示
DOI：
10.1002/jmv.25217
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发表时间：
2018-09-01
影响因子：
12.7
通讯作者：
Cai, Qiliang
中科院分区：
文献类型：
--
作者：
Ding, Ling;Mo, Xiaohui;Cai, Qiliang
皮肤病的症状和严重程度差异很大，这些疾病的原因在很大程度上是未知的。人类疱疹病毒（Human herpesvirus，HHV）可引起多种疾病。然而，每种HHV感染与不同皮肤病的患病率和相关性仍然不清楚。为了揭示某种类型的皮肤病与疱疹病毒感染的潜在联系，对中国上海地区共272例炎性或肿瘤性皮肤病患者组织（包括7种亚型）进行了调查。我们发现HHV-6A在炎症或肿瘤性皮肤组织中的总体患病率是最常见的，（40.3%），其次是爱泼斯坦-巴尔病毒（17.6%），卡波西肉瘤相关疱疹病毒（KSHV; 9.2%），HHV-6B（4.4%），人巨细胞病毒（1.1%）和水痘带状疱疹病毒（0.7%）;尽管HHV-6A、爱泼斯坦-巴尔病毒和KSHV的合并感染程度较低，但未检出HSV-1、HSV-2或HHV-7。此外，HHV-6A感染与痣细胞痣和脂溢性皮炎/角化病高度相关，主要发生在头颈部或下肢。尽管不同年龄组皮肤患者组织中HHV感染之间无显著差异，但KSHV感染在男性皮肤患者中的分布仅显著较高（约3.7倍）。
Skin disorders vary greatly in symptom and severity, and the causes of these disorders are largely unknown. Human herpesvirus (HHV) has been shown to cause many diseases. However, the prevalence and correlation of each HHV infection with different skin disorders remains obscure. To reveal the potential link of a certain type of skin disease with herpesvirus infection, a total of 272 patient tissues with inflammatory or neoplastic skin diseases including 7 subtypes in Shanghai, China, were investigated. We found that the overall prevalence of HHV‐6A in inflammatory or neoplastic skin tissues is the most common (40.3%), followed by Epstein‐Barr virus (17.6%), Kaposi’s sarcoma‐associated herpesvirus (KSHV; 9.2%), HHV‐6B (4.4%), human cytomegalovirus (1.1%), and varicella‐zoster virus (0.7%); albeit the co‐infection of HHV‐6A, Epstein‐Barr virus, and KSHV presents to a less extent and none of HSV‐1, HSV‐2, or HHV‐7 were detected. Moreover, HHV‐6A infection is highly associated with nevocytic nevus and seborrheic dermatitis/keratosis diseases, which mainly occur in the head and the neck or the lower limb. Despite no significant difference among the HHV infections in different age groups of skin patient tissues, the distribution of KSHV infection was exclusively and significantly higher (~3.7‐fold) in male skin patients.