Antioxidant prenylated flavonoids from propolis collected in Okinawa, Japan
Antioxidant prenylated flavonoids from propolis collected in Okinawa, Japan
复制标题
DOI：
10.1021/jf071187h
复制
发表时间：
2007-09-19
影响因子：
6.1
通讯作者：
Nakayama, Tsutomu
中科院分区：
文献类型：
--
作者：
Kumazawa, Shigenori;Ueda, Reika;Nakayama, Tsutomu
蜂胶是蜜蜂从各种植物中收集的一种可吸收物质。植物的组成取决于采集地点的植被。我们以前从日本冲绳采集的枸杞中分离出四种异戊烯化黄酮。在这项研究中，进一步分馏的提取物的冲绳导致在分离的一个新的异戊烯化类黄酮，原kinawan，和四个已知的化合物。用质谱和核磁共振波谱法确定了原基那万的结构。此外，使用1，1-二苯基-2-苦基-肼基自由基清除和β-胡萝卜素漂白系统的抗氧化活性进行了研究。本研究证明，香叶基或异戊烯基在黄酮骨架上的位置在显示抗氧化活性方面起着重要作用。
Propolis is a resinous substance collected by honeybees from various plant sources. The composition of propolis depends upon the vegetation at the site of collection. We previously isolated four prenylated flavonoids from propolis collected in Okinawa, Japan. In this study, further fractionation of the extracts of Okinawan propolis resulted in the isolation of a new prenylated flavonoid, prokinawan, and four known compounds. The structure of prokinawan was determined by MS and NMR spectroscopic methods. Furthermore, the antioxidant activity using 1,1-diphenyl-2-picryl-hydrazyl radical scavenging and beta-carotene bleaching systems was investigated. The present study proved that the position of the geranyl or prenyl groups on the flavonoid skeleton plays an important role in exhibiting antioxidant activity.