History of atopy or autoimmunity increases risk of alopecia areata
History of atopy or autoimmunity increases risk of alopecia areata
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DOI：
10.1016/j.jaad.2009.04.031
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发表时间：
2009-10-01
影响因子：
13.8
通讯作者：
Duvic, Madeleine
中科院分区：
文献类型：
--
作者：
Barahmani, Nazila;Schabath, Matthew B.;Duvic, Madeleine
背景：特应性或自身免疫性疾病史与斑秃（AA）风险之间的关系尚未得到很好的确定。本研究的目的是使用国家AA登记数据库，以进一步研究过敏性或自身免疫性疾病的历史和AA的风险之间的关联。累计自行登记散发病例2613例结果：有过敏史者2055例，对照组558例，（比值比= 2.00; 95%置信区间1.50-2.54）或自身免疫性（比值比= 1.73; 95%置信区间1.10-2.72）疾病与AA风险增加相关。有一种以上的特应性或自身免疫性疾病史和AA风险增加的趋势。召回，报告和招聘偏见是潜在的来源，在此analys.Conclusion：本分析显示，过敏性和自身免疫性疾病的历史与AA的风险增加，结果是一致的严重的AA亚型（即全秃和普秃）和本地化的亚型（即AA持续）。（J Am Acad Dermatol 2009;61：581-91.）
Background: The association between a history of atopy or autoimmune diseases and risk of alopecia areata (AA) is not well established.Objective. The purpose of this study was to use the National AA Registry database to further investigate the association between history of atopy or autoimmune diseases and risk of AA.Methods. A total of 2613 self-registered sporadic cases (n = 2055) and controls (n = 558) were included in this analysis.Results: Possessing a history of any atopic (odds ratio = 2.00; 95% confidence interval 1.50-2.54) or autoimmune (odds ratio = 1.73; 95% confidence interval 1.10-2.72) disease was associated with an increased risk of AA. There was no trend for possessing a history of more than one atopic or autoimmune disease and increasing risk of AA.Limitations. Recall, reporting, and recruiting bias are potential sources of limitations in this analysis.Conclusion: This analysis revealed that a history of atopy and autoimmune disease was associated with an increased risk of AA and that the results were consistent for both the severe Subtype of AA (i.e, alopecia totalis and alopecia universalis) and the localized subtype (ie, AA persistent). (J Am Acad Dermatol 2009;61:581-91.)