The effects of psychological stress on humans: Increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety
The effects of psychological stress on humans: Increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety
复制标题
DOI：
10.1006/cyto.1997.0290
复制
发表时间：
1998-04-01
期刊：
影响因子：
3.8
通讯作者：
Smith, RS
中科院分区：
文献类型：
--
作者：
Maes, M;Song, C;Smith, RS
有一些证据表明，在人类和实验动物中，心理应激可能抑制或增强免疫功能，这取决于应激源的性质和所考虑的免疫变量，心理应激可能影响促炎和免疫调节细胞因子产生的可能性在38名医学生中进行了调查，他们在考试前几周和考试后几周以及考试前一天都进行了血液采样。心理应激显著增加了肿瘤坏死因子α（TNF-α）、白细胞介素6（IL-6）、IL-1受体拮抗剂（IL-1 Ra）、干扰素γ（IFN-γ）和IL-10的刺激产生。在压力条件下具有高压力感知的学生比具有低压力感知的学生产生更高的TNF-α，IL-6，IL-1 Ra和IFN-γ。与没有焦虑的学生相比，具有高焦虑反应的学生产生的IFN-γ显著较高，而产生的负性免疫调节细胞因子IL-10和IL-4较低。这些发现表明，在人类中，促炎细胞因子TNF-α、IL-6和IFN-γ以及负性免疫调节细胞因子IL-10和IL-4的产生的变化参与了对心理应激的稳态反应，并且应激诱导的焦虑与T辅助细胞-1样反应有关。(C)出版社：Academic Press Limited。
There is some evidence that, in humans and experimental animals, psychological stress may suppress or enhance immune functions, depending on the nature of the stressor and the immune variables under consideration, The possibility that psychological stress may affect the production of pro-inflammatory and immunoregulatory cytokines was investigated in 38 medical students, who had blood samplings a few weeks before and after as well as one day before an academic examination. Psychological stress significantly increased the stimulated production of tumour necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), IL-1 receptor antagonist (IL-1Ra), interferon gamma (IFN-gamma) and IL-10. Students with high stress perception during the stressful condition had a significantly higher production of TNF-alpha, IL-6, IL-1Ra and IFN-gamma than students with a low-stress perception. Students with a high anxiety response had a significantly higher production of IFN-gamma and a lower production of the negative immunoregulatory cytokines, IL-10 and IL-4, than students without anxiety. These findings suggest that, in humans, changes in the production of the pro-inflammatory cytokines, TNF-alpha, IL-6 and IFN-gamma, and negative immunoregulatory cytokines, IL-10 and IL-4, take part in the homeostatic responses to psychological stress and that stress-induced anxiety is related to a T-helper-1-like response. (C) 1998 Academic Press Limited.