Urinary Excretion of Purine and Pyrimidine Metabolites in the Neonate
Urinary Excretion of Purine and Pyrimidine Metabolites in the Neonate
复制标题
新生儿嘌呤和嘧啶代谢物的尿排泄
DOI：
10.1203/00006450-199312000-00012
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发表时间：
1993
影响因子：
3.6
通讯作者：
S. Scharpé
中科院分区：
文献类型：
--
作者：
K. J. Acker;F. Eyskens;R. Verkerk;S. Scharpé
摘要：随机抽取614例新生儿尿样，采用柱层析法检测嘌呤和嘧啶代谢产物。色谱图上出现有限数量的代谢物和许多未鉴别峰。未发现这种代谢的先天性缺陷。足月儿和早产儿或发育不良新生儿的色谱图是相同的，除了后者组中存在更多未识别的峰。该模式不受喂养类型或静脉营养的影响。确定了不同药物的代谢产物。1例尿嘧啶排泄增加的女性新生儿显示为鸟氨酸氨甲酰转移酶缺乏症杂合子。
ABSTRACT: Random urine samples from 614 neonates were screened for metabolites of purine and pyrimidine metabolism using an adapted column chromatographic method. A restricted number of metabolites and a number of unidentified peaks appeared on the chromatograms. No inborn errors of this metabolism were found. The chromatograms were identical in term and in premature or dysmature neonates, except for the presence of more unidentified peaks in the latter group. The pattern was not influenced by the type of feeding or i.v. nutrition. Metabolites of different medications were identified. One female neonate with an increased excretion of uracil was shown to be heterozygous for ornithine carbamyl transferase deficiency.