Diet-Microbiome Interactions in Health Are Controlled by Intestinal Nitrogen Source Constraints
Diet-Microbiome Interactions in Health Are Controlled by Intestinal Nitrogen Source Constraints
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DOI：
10.1016/j.cmet.2016.10.021
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发表时间：
2017-01-10
期刊：
影响因子：
29
通讯作者：
Simpson, Stephen J.
中科院分区：
文献类型：
--
作者：
Holmes, Andrew J.;Chew, Yi Vee;Simpson, Stephen J.
饮食影响人群的健康和疾病模式。不同的饮食如何做到这一点，以及为什么饮食的结果在个体之间存在差异是复杂的，并且涉及与肠道微生物组的相互作用。预测宿主微生物组动态的健康结果的一个主要挑战是协调饮食的不同方面（食物组成或摄入率）对系统的影响。在这里，我们表明，微生物群落组装是从根本上塑造了一个二分法的细菌策略，以获得氮在肠道环境中。因此，膳食蛋白质摄入的模式以非常广泛的饮食操纵策略所共有的方式限制宿主微生物组动态。这些见解为高蛋白质摄入对代谢健康的影响提供了机制，并为不同饮食策略对宿主微生物组结果的影响的一般理论奠定了基础。
Diet influences health and patterns of disease in populations. How different diets do this and why outcomes of diets vary between individuals are complex and involve interaction with the gut microbiome. A major challenge for predicting health outcomes of the host-microbiome dynamic is reconciling the effects of different aspects of diet (food composition or intake rate) on the system. Here we show that microbial community assembly is fundamentally shaped by a dichotomy in bacterial strategies to access nitrogen in the gut environment. Consequently, the pattern of dietary protein intake constrains the host-microbiome dynamic in ways that are common to a very broad range of diet manipulation strategies. These insights offer a mechanism for the impact of high protein intake on metabolic health and form the basis for a general theory of the impact of different diet strategies on host-microbiome outcomes.