Prevalence of diabetes mellitus secondary to pancreatic diseases (type 3c)
Prevalence of diabetes mellitus secondary to pancreatic diseases (type 3c)
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DOI：
10.1002/dmrr.2260
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发表时间：
2012-05-01
影响因子：
8
通讯作者：
Hardt, P. D.
中科院分区：
文献类型：
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作者：
Ewald, N.;Kaufmann, C.;Hardt, P. D.
背景糖尿病继发于胰腺疾病是一种在临床实践中很少考虑的疾病。然而，在一般人群中，特别是糖尿病受试者中，胰腺外分泌功能不全的比例很高。因此，我们调查了胰腺疾病导致糖尿病的患病率。方法对我院24年来收治的1868例糖尿病患者进行问卷调查。个月对患者数据进行了认真研究，并根据美国糖尿病协会提出的糖尿病分类对患者进行了重新分类。结果1868例患者中，3c型糖尿病172例（9.2%）。其中慢性胰腺炎135例（78.5%），遗传性血色病12例，胰腺癌14例，囊性纤维化7例。因此，在所有糖尿病受试者中，7.2%的人因慢性胰腺炎而发生糖尿病。这些患者的错误分类非常常见。只有51.2%（88/172）的患者最初被正确分类。大多数3型糖尿病患者最初被错误分类为2型糖尿病（69/84）。结论糖尿病继发于胰腺疾病（尤其是慢性胰腺炎）似乎比一般认为的更常见，在这里研究的对象中的患病率为9.2%。由于对这种糖尿病类型的认识很差，错误分类是相当频繁的。一个常见的问题似乎是2型和3型之间的区别。然而，糖尿病的正确分类很重要，因为继发于胰腺疾病的糖尿病患者有特殊的治疗选择和问题。版权所有（C）2011约翰威利父子有限公司
Background Diabetes mellitus secondary to pancreatic diseases is a condition seldom thought of in clinical practice. Yet, a high percentage of exocrine pancreatic insufficiency has been reported for the general population and especially for diabetic subjects. Thus, we investigated the prevalence of diabetes mellitus due to pancreatic diseases. Methods In this study, we investigated 1868 patients diagnosed with diabetes mellitus who had been admitted to our hospital during the last 24?months. Patient data were diligently studied, and patients were reclassified according to the diabetes classification as proposed by the American Diabetes Association. Results Among 1868 subjects, 172 patients could be classified as type 3c diabetes mellitus (9.2%). Among these were 135 diagnosed with chronic pancreatitis (78.5%), 12 with hereditary haemochromatosis, 14 with pancreatic cancer and 7 with cystic fibrosis. Thus, diabetes mellitus due to chronic pancreatitis occurred in this collective in 7.2% of all diabetic subjects. Misclassification of these patients was very common. Only 51.2% (88/172) were initially classified correctly. Most type 3 diabetes patients were initially misclassified as type 2 diabetes (69/84). Conclusions Diabetes mellitus secondary to pancreatic diseases (especially chronic pancreatitis) seems more common than generally believed with a prevalence of 9.2% among the subjects studied here. Because the awareness of this diabetes type is poor, misclassification is quite frequent. A common problem seems to be the differentiation between type 2 and type 3. Yet, the right classification of diabetes mellitus is important, because there are special therapeutic options and problems in patients with diabetes secondary to pancreatic diseases. Copyright (C) 2011 John Wiley & Sons, Ltd.