Crossfostering. A research strategy for clarifying the role of genetic and experiential factors in the etiology of schizophrenia.
Crossfostering. A research strategy for clarifying the role of genetic and experiential factors in the etiology of schizophrenia.
复制标题
交叉培养。
DOI：
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
J. Welner
中科院分区：
文献类型：
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作者：
P. Wender;D. Rosenthal;S. Kety;F. Schulsinger;J. Welner
一种阐明经验因素在精神病理学中的作用的技术——交叉抚养技术——采用的策略是使用由精神分裂症父母抚养的正常亲生父母收养的后代。将该群体与正常养父母抚养的正常亲生父母的被收养后代和正常养父母抚养的精神分裂症亲生父母的被收养后代进行比较。对这些被收养者的精神病理学分析表明，精神分裂症患者被收养的后代中精神病理学的患病率更高，而在交叉抚养组中则没有这种增加。该研究的初步结论是，遗传因素在精神分裂症的病因学中起作用，而家族性精神病理学（通过父母的精神诊断来衡量）则没有作用。考虑了家庭外生物和心理经验的可能作用。
A technique for clarifying the role of experiential factors in psychopathology-the crossfostering technique-employs the strategy of using adopted-away offspring of normal biological parents who are reared by schizophrenic parents. This group is compared with the adopted-away offspring of normal biological parents reared by normal adopting parents and the adopted-away offspring of schizophrenic biological parents reared by normal adopting parents. Analyses of psychopathology in these adoptees reveals that there is a greater prevalence of psychopathology among the adopted-away offspring of schizophrenics while no such increase is seen among the crossfostered group. The tentative conclusion of the study is that genetic factors play a role in the etiology of the schizophrenias while familial psychopathology (as measured by psychiatric diagnosis of the parents) does not. The possible roles of extrafamilial biological and psychological experience are considered.