Assessment of uterine artery geometry and hemodynamics in human pregnancy with 4d flow mri and its correlation with doppler ultrasound.
Assessment of uterine artery geometry and hemodynamics in human pregnancy with 4d flow mri and its correlation with doppler ultrasound.
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DOI：
10.1002/jmri.26229
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Witschey WRT
中科院分区：
文献类型：
--
作者：
Hwuang E;Vidorreta M;Schwartz N;Moon BF;Kochar K;Tisdall MD;Detre JA;Witschey WRT
子宫动脉（UtA）血流动力学可用于预测妊娠期高血压疾病的风险，包括先兆子痫和宫内生长受限。通过描述UtA解剖结构、计算UtA流量并将UtA速度、脉动性和电阻率指数（PI、RI）与经腹多普勒超声（US）进行比较，确定4D flow MRI在妊娠受试者中的可行性。2016年6月6日至2018年5月2日的前瞻性横断面研究。41例妊娠中期或晚期的单胎妊娠受试者（年龄[范围] = 27.0 ± 5.9 [18-41]岁）。我们还扫描了三名患有孕前糖尿病或慢性高血压的受试者。受试者接受UtA和胎盘MRI，使用非造影剂血管造影和1.5T的4D血流。根据4D血流衍生的非造影剂血管造影描述UtA解剖结构，而通过检查4D血流数据，通过净流量、收缩/平均/舒张速度、PI和RI表征UtA血流特性。PI和RI是多普勒超声常规报告的标准血流动力学参数。采用斯皮尔曼秩相关、Wilcoxon符号秩检验和Bland-Altman图对血流参数、胎龄和多普勒超声之间的关系进行初步研究。4D flow MRI和UtA血流定量在所有受试者中均可行。每例受试者的UtA几何结构在左右UtA之间以及受试者之间存在相当大的异质性。平均4D血流参数为：平均双侧流速= 605.6 ± 220.5 mL/min，PI = 0.72 ± 0.2，RI = 0.47 ± 0.1。双侧血流不随胎龄变化。我们发现MRI与US在PI（平均差异-0.1）和RI（平均差异<-0.1）较低方面存在差异，Wilcoxon符号秩检验分别为P = 0.05和P = 0.13。4D flow MRI是描述妊娠受试者UtA解剖结构和血流的可行方法。阶段1
Uterine artery (UtA) hemodynamics might be used to predict risk of hypertensive pregnancy disorders, including preeclampsia and intrauterine growth restriction. To determine the feasibility of 4D flow MRI in pregnant subjects by characterizing UtA anatomy, computing UtA flow, and comparing UtA velocity, and pulsatility and resistivity indices (PI, RI) with transabdominal Doppler ultrasound (US). Prospective cross-sectional study from June 6, 2016, to May 2, 2018. Forty-one singleton pregnant subjects (age [range] = 27.0 ± 5.9 [18–41] years) in their second or third trimester. We additionally scanned three subjects who had prepregnancy diabetes or chronic hypertension. The subjects underwent UtA and placenta MRI using noncontrast angiography and 4D flow at 1.5T. UtA anatomy was described based on 4D flow-derived noncontrast angiography, while UtA flow properties were characterized by net flow, systolic/mean/diastolic velocity, PI and RI through examination of 4D flow data. PI and RI are standard hemodynamic parameters routinely reported on Doppler US. Spearman’s rank correlation, Wilcoxon signed rank tests, and Bland-Altman plots were used to preliminarily investigate the relationships between flow parameters, gestational age, and Doppler US. 4D flow MRI and UtA flow quantification was feasible in all subjects. There was considerable heterogeneity in UtA geometry in each subject between left and right UtAs and between subjects. Mean 4D flow-based parameters were: mean bilateral flow rate = 605.6 ± 220.5 mL/min, PI = 0.72 ± 0.2, and RI = 0.47 ± 0.1. Bilateral flow did not change with gestational age. We found that MRI differed from US in terms of lower PI (mean difference −0.1) and RI (mean difference < −0.1) with Wilcoxon signed rank test P = 0.05 and P = 0.13, respectively. 4D flow MRI is a feasible approach for describing UtA anatomy and flow in pregnant subjects. Stage 1
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影响因子：
9.8
作者：
Ilekis JV;Tsilou E;Fisher S;Abrahams VM;Soares MJ;Cross JC;Zamudio S;Illsley NP;Myatt L;Colvis C;Costantine MM;Haas DM;Sadovsky Y;Weiner C;Rytting E;Bidwell G
通讯作者：
Bidwell G
影响因子：
3.3
作者：
Bock, Jelena;Frydrychowicz, Alex;Markl, Michael
通讯作者：
Markl, Michael
影响因子：
3.8
作者：
Hawkes, R. A.;Patterson, A. J.;Lomas, D. J.
通讯作者：
Lomas, D. J.
影响因子：
7.1
作者：
Bhide, A.;Acharya, G.;Trudinger, B.
通讯作者：
Trudinger, B.
影响因子：
7.2
作者：
Copel, Joshua;El-Sayed, Yasser;Wharton, Kurt R.
通讯作者：
Wharton, Kurt R.