Quantification of MRI lesion load in multiple sclerosis: A comparison of three computer-assisted techniques
Quantification of MRI lesion load in multiple sclerosis: A comparison of three computer-assisted techniques
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DOI：
10.1016/0730-725x(96)00018-5
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发表时间：
1996-01-01
影响因子：
2.5
通讯作者：
Miller, DH
中科院分区：
文献类型：
--
作者：
Grimaud, J;Lai, M;Miller, DH
已经开发了几种用于测量MR图像上的多发性硬化病变负荷的计算机辅助技术，以提供用于监测疾病活动的定量和灵敏的手段，特别是在治疗试验的背景下。我们已经评估了三种技术：手动勾画（类似于北美干扰素β-lb试验），半自动病变轮廓（局部病变阈值），和基于强度的阈值为整个大脑。同时，对8例临床确诊的多发性硬化患者在1.5T磁共振成像仪上获得了5 mm厚的轴向T2加权像。由三名操作员使用三种不同的技术对扫描进行两次独立分析。测量技术的变异系数为：（a）批内精密度，9.0 +/- 5.2（平均值+/- SD）（范围0.4-18.5）手动轮廓，2.5 +/- 2.1轮廓技术为（0.1-7.7），7.5 ± 6.9（0.2-22.0）用于全局阈值技术;（B）评分员间精密度，11.0 +/- 5.8（4.9-21.7），轮廓技术为4.5 +/- 1.6（1.8-6.6），全局阈值技术为11.4 +/- 4.9（2.8-19.2）（0.0 =完美精度）。使用手动勾画和轮廓技术测得的绝对损伤载荷非常相似，但使用全局阈值技术测得的绝对损伤载荷明显较小。我们的结论是轮廓技术是一个很有前途的工具，用于治疗试验。需要进一步的研究来评估病变负荷随时间变化的敏感性。
Several computer-assisted techniques for measuring multiple sclerosis lesion load on MR images have been developed to provide a quantitative and sensitive means for monitoring disease activity, particularly in the context of treatment trials. We have evaluated three techniques: manual outlining (similar to that of the North American interferon beta-lb trial), semiautomated lesion contouring (local lesion based threshold), and intensity-based thresholding for the whole brain. Contiguous, 5 mm-thick, axial, T-2-weighted images of the brain were obtained on a 1.5T MR imager in eight patients with clinically definite multiple sclerosis. Analyses of the scans were performed twice, independently by three operators, using the three different techniques. The coefficient of variation of the measurement techniques was: (a) intrarater precision, 9.0 +/- 5.2 (mean +/- SD) (range 0.4-18.5) for the manual outlining, 2.5 +/- 2.1 (0.1-7.7) for the contour technique, and 7.5 +/- 6.9 (0.2-22.0) for the global threshold technique; (b) interrater precision, 11.0 +/- 5.8 (4.9-21.7) for the manual outlining, 4.5 +/- 1.6 (1.8-6.6) for the contour technique, and 11.4 +/- 4.9 (2.8-19.2) for the global threshold technique (0.0 = perfect precision). The absolute lesion loads measured were very similar using the manual outlining and the contour techniques but were significantly smaller using the global threshold technique. We conclude that the contour technique is a promising tool for use in treatment trials. Further studies are needed to assess sensitivity to changes in lesion load over time.