Histopathological reactions of calcium phosphate cement.
Histopathological reactions of calcium phosphate cement.
复制标题
磷酸钙骨水泥的组织病理学反应。
作者：
A. Sugawara;M. Nishiyama;K. Kusama;I. Moro;S. Nishimura;I. Kudo;L. Chow;S. Takagi
磷酸钙水泥（CPC）由Ca4 (PO4)2O和CaHPO4 （2H2O）组成。本研究将CPC和CPC混合物与商用羟基磷灰石（HP）和几种根管材料(Grossman’s cement （GC)，氢氧化钙碘膏（CHP）和杜仲胶板（GP））进行了体内比较。1个月后观察皮下植入物在东流大鼠体内的生物相容性。结果显示，CPC、CPC混合物和HP的炎症反应非常轻微。材料被薄纤维结缔组织包裹，有少量淋巴细胞和浆细胞。GC引起了严重的炎症反应。CHP诱导的肉芽组织与假黄瘤性肉芽肿相似。GP材料被较厚的纤维结缔组织包裹，炎症反应小。
Calcium phosphate cement (CPC) consisting of Ca4 (PO4)2O and CaHPO4 (2H2O) was recently developed. This study evaluated in vivo aspects of CPC and CPC mixtures compared to those of commercial hydroxyapatite (HP) and several endodontic materials: Grossman's cement (GC), calcium hydroxide-iodine paste (CHP) and gutta-percha plate (GP). Biocompatibility of subcutaneous implants in Donryu rats was evaluated after one month. Results showed very slight inflammatory reactions from CPC, CPC mixtures and HP. The materials were surrounded by thin fibrous connective tissues with a small number of lymphocytes and plasma cells. Severe inflammatory reactions were provoked by GC. Granulation tissues induced by CHP resembled those of pseudoxanthomatous granuloma. The GP material was encapsulated by relatively thick fibrous connective tissues with little inflammatory reactions.