DAY-TO-DAY VARIATION OF 24-HOUR INTRAGASTRIC ACIDITY
DAY-TO-DAY VARIATION OF 24-HOUR INTRAGASTRIC ACIDITY
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DOI：
10.1016/0016-5085(88)90543-4
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发表时间：
1988-04-01
期刊：
影响因子：
29.4
通讯作者：
ROHMEL, J
中科院分区：
文献类型：
--
作者：
MERKI, HS;WITZEL, L;ROHMEL, J
用胃内电极连续测定13名健康志愿者24小时胃内酸度，共研究4次。受试者在医院接受了两次研究，在门诊接受了两次研究。严格控制饮食条件，并比较重复研究，以评估此类酸度记录的可变性。评估了该技术的准确性，并计算了常用时间段的差异检测下限。在24小时内，在夜间、白天和晚上，该技术能够检测到>；0.1单位的pH持续变化。在不同的5分钟时间内，检测的限度要大得多。这项研究证实了24小时胃内酸度的变异性，并证实连续监测能够在住院和门诊条件下检测到重要的酸度变化。
Twenty-four-hour intragastric acidity was measured continuously using an intragastric electrode in 13 normal volunteers studied four times. Subjects were studied twice in the hospital and twice as outpatients. The dietary conditions were strictly controlled and the replicate studies were compared to assess the variability of such recordings of acidity. The accuracy of the technique was assessed, and a detection limit for differences were calculated for commonly used time periods. Over 24 h, during the night, during the day, and during the evening the technique is able to detect consistent changes of pH of > 0.1 units. During separate 5-min periods the limits of detection were considerably greater. This study demonstrates the variability of 24-h intragastric acidity and confirms that continuous monitoring is able to detect important changes of acidity under both hospitalized and ambulant conditions.