Heritability of longitudinal changes in coronary-heart-disease risk factors in women twins
Heritability of longitudinal changes in coronary-heart-disease risk factors in women twins
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DOI：
10.1086/515462
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发表时间：
1997-06-01
影响因子：
9.8
通讯作者：
King, MC
中科院分区：
文献类型：
--
作者：
Friedlander, Y;Austin, MA;King, MC
许多研究已经证明遗传对冠心病（CHD）危险因素水平的影响，但随着时间的推移，这些危险因素的个体内变异也可能受到遗传影响。危险因素的变化可能反映了遗传-环境的相互作用，并可能对理解CHD风险具有重要意义。本研究利用Kaiser Permanente妇女双胞胎研究的两次检查的数据，研究了CHD危险因素变化的遗传性，两次检查相隔十年。样本包括348对女性双胞胎谁参加了这两项检查，其中包括203 MZ对和145 DZ对。两次检查的平均年龄分别为41岁和51岁。通过三种不同的统计分析方法，证明了LDL胆固醇（h（2）= .25 - .36）和HDL胆固醇（h（2）= .23 - .58）变化的中等遗传力估计值，其中一些具有统计学意义。虽然收缩压的遗传度估计值为小到中等（.18 - .37;某些估计值P < .05），但未检测到舒张压变化的遗传影响。基于女性双胞胎的纵向数据，这项研究证明了遗传对脂蛋白危险因素和收缩压的变化的影响超过十年。除了明显起作用的环境因素外，各种“变异性基因”的作用可能独立于遗传因素对这些风险因素绝对水平的影响。绘制这些CHD风险因素的个体内变异的基因并了解其功能可能会导致有针对性的干预策略，以降低遗传易感个体的CHD风险。
Numerous studies have demonstrated genetic influences on levels of coronary heart disease (CHD) risk factors, but there also may be genetic effects on the intraindividual variation in these risk factors over time. Changes in risk factors are likely to reflect genetic- environmental interactions and may have important implications for understanding CHD risk. The present study examines the heritability of changes in CHD risk factors, using data from the two examinations by the Kaiser Permanente Women Twins Study, performed a decade apart. The sample consisted of 348 pairs of women twins who participated in both examinations, including 203 MZ pairs and 145 DZ pairs. Average ages at the two examinations were 41 and 51 years, respectively. By means of three different statistical analytic approaches, moderate heritability estimates were demonstrated for changes in LDL cholesterol (h(2) = .25 - .36) and in HDL cholesterol (h(2) = .23 - .58), some of which were statistically significant. Although small to moderate heritability estimates were found for systolic blood pressure (.18 - .37; P < .05 for some estimates), no genetic influence on changes in diastolic blood pressure was detected. Based on longitudinal twin data in women, this study demonstrates a genetic influence on changes in both lipoprotein risk factors and systolic blood pressure over a decade. In addition to environmental factors, which clearly are operating, the effect of various ''variability genes'' may be acting independently of the genetic influences on the absolute levels of these risk factors. Both mapping the gene(s) underlying intraindividual variations in these CHD risk factors and understanding their function(s) could lead to targeted intervention strategies to reduce CHD risk among genetically susceptible individuals.