Localization of premotoneurons for an NMDA-induced repetitive rhythmical activity to TMNs
Localization of premotoneurons for an NMDA-induced repetitive rhythmical activity to TMNs
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NMDA 诱导的 TMN 重复节律活动的前运动神经元定位
DOI：
10.1097/00001756-200212030-00027
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发表时间：
2002
期刊：
影响因子：
1.7
通讯作者：
T. Yamanishi
中科院分区：
文献类型：
--
作者：
A. Enomoto;M. Kogo;H. Koizumi;K. Ishihama;T. Yamanishi
三叉神经节律活动的运动前神经元的定位或特征尚未明确。我们研究了产生nmda诱导的三叉神经运动神经元（TMNs）重复性节律活动的运动前神经元的定位。这种节律性活动的最小电路是通过从新生大鼠（0-3天大）分离的脑干的碎片切片制备来确定的。在兴奋性氨基酸激动剂NMA和GABAA受体拮抗剂bicuculline methioide （BIC）存在的情况下，我们使用整个和碎片化的脑干切片制备三叉神经运动核，记录TMNs的节律性神经活动。颞下颌神经网络接收由nmda诱导的运动前神经元的节律性活动的投射，这些活动位于三叉神经运动核周围300 μm的区域。NMA （20 μM）和BIC （10 μM）诱导TMNs的重复性节律活动。
The localization or characteristics of the premotoneurons for trigeminal rhythmical activity have not been clarified. We investigated the localization of premotoneurons generating an NMDA-induced repetitive rhythmical activity to trigeminal motoneurons (TMNs). The minimal circuitry for this rhythmical activity was determined using a fragmented slice preparation of the isolated brain stem from neonatal rats (0–3 days old). We recorded rhythmical neural activities from TMNs using whole and fragmented brainstem slices preparation including the trigeminal motor nucleus in the presence of the excitatory amino acid agonist NMA and the GABAA receptor antagonist, bicuculline methiodide (BIC). TMNs receive projections from premotoneurons for an NMDA-induced rhythmical activity, which can be located in the area 300 μm surrounding the trigeminal motor nucleus. NMA (20 μM) and BIC (10 μM) induced repetitive rhythmical activities on TMNs.