Relation of dosage and time of administration of diphenylhydantoin to its teratogenic effect in mice.
Relation of dosage and time of administration of diphenylhydantoin to its teratogenic effect in mice.
复制标题
二苯乙内酰脲的剂量和给药时间与其对小鼠的致畸作用的关系。
DOI：
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发表时间：
1969
期刊：
影响因子：
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通讯作者：
Bernard A. Becker
中科院分区：
文献类型：
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作者：
Raymond D. Harbison;Bernard A. Becker
二苯基苯妥英对小鼠有致畸作用，可引起胎儿死亡。大多数死亡发生在第10、11、12、14和15天。单次给药后第9 ~ 15天，胎儿体重呈剂量相关性显著降低。单次注射二苯基苯妥英可引起睁眼、趾外畸形、唇裂、腭裂、肾积水和内部脑积水。骨骼缺陷包括胸骨或颈椎中心不完全骨化、胸骨不融合和椎体融合。长骨以一天和剂量依赖的方式缩短。死亡率、致畸和对胎儿生长的影响是日和剂量依赖性的，产生的异常谱也是如此。
Diphenylhydantoin was teratogenic and caused prenatal death in Swiss-Webster mice. Most deaths resulted after single treatment on days 10, 11, 12, 14, and 15. Fetal body weight was significantly reduced in a dose-related manner after single treatment on days 9 to 15. Single injections of diphenylhydantoin produced open eye, ectrodactyly, cleft lip, cleft palate, hydronephrosis, and internal hydrocephalus. Skeletal defects noted were incomplete ossification of sternebrae or cervical centra, unfused sternebrae, and fused vertebrae. Long bones were shortened in a day- and dosage-dependent fashion. Mortality, teratogenesis, and effect on fetal growth were day- and dosage-dependent as was the spectrum of anomalies produced.