Immunologists getting nervous: neuropeptides, dendritic cells and T cell activation.
Immunologists getting nervous: neuropeptides, dendritic cells and T cell activation.
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DOI：
10.1186/rr49
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发表时间：
2001
影响因子：
5.8
通讯作者：
Lambrecht, B N
中科院分区：
文献类型：
--
作者：
Lambrecht, B N
越来越多的人认识到，免疫系统和神经系统紧密结合，以优化肺部的防御系统。本文就P物质、降钙素基因相关肽、血管活性肠肽和生长抑素等神经肽在调节T细胞活化中的作用作一综述。这些神经肽不仅从神经末梢释放，而且从炎性免疫细胞如单核细胞、树突细胞、嗜酸性粒细胞和肥大细胞释放。在释放时，它们可以对T细胞活化发挥直接刺激和抑制作用，也可以通过它们对专职抗原呈递树突状细胞的募集和活化的影响发挥间接作用。因此，神经肽应该被包括在树突状细胞对T细胞功能的免疫调节的概念框架中。
It is increasingly recognised that the immune and nervous systems are closely integrated to optimise defence systems within the lung. In this commentary, the contribution of various neuropeptides such as substance P, calcitonin gene-related peptide, vasoactive intestinal peptide and somatostatin to the regulation of T cell activation is discussed. These neuropeptides are released not only from nerve endings but also from inflammatory immune cells such as monocytes, dendritic cells, eosinophils and mast cells. On release they can exert both direct stimulatory and inhibitory effects on T cell activation and also indirect effects through their influence on the recruitment and activation of professional antigen-presenting dendritic cells. Neuropeptides should therefore be included in the conceptual framework of the immune regulation of T cell function by dendritic cells.