Effect of reduced dietary sodium on blood pressure - A meta-analysis of randomized controlled trials
Effect of reduced dietary sodium on blood pressure - A meta-analysis of randomized controlled trials
复制标题
DOI：
10.1001/jama.275.20.1590
复制
发表时间：
1996-05-22
影响因子：
120.7
通讯作者：
Logan, AG
中科院分区：
文献类型：
--
作者：
Midgley, JP;Matthew, AG;Logan, AG
客观。-为了确定是否限制饮食钠降低血压高血压和血压正常的个人。数据来源。进行了英语计算机文献检索，仅限于使用医学主题标题术语“高血压”、“血压”、"血管阻力“、”钠和饮食“、”饮食和限钠“、”氯化钠“、”临床试验“、”随机对照试验“和”前瞻性研究“的人体研究。还检索了综述文章的参考书目和个人档案。随机分配到对照组和饮食钠干预组的试验，通过定时钠排泄监测，收缩压和舒张压的结局指标通过方法部分的盲法审查选择。数据提取。两名观察员使用专门设计的表格独立提取数据，并通过讨论解决差异。符合我们纳入标准的56项试验显示出显著的异质性。发表偏倚也很明显。在28项试验（1131例高血压受试者）和28项试验（2374例血压正常受试者）中，每日尿钠排泄（膳食钠摄入量的替代指标）的平均减少（95%置信区间）分别为95 mmol/d（71-119 mmol/d）和125 mmol/d（95-156 mmol/d）。校正尿钠排泄量测量误差后，每日减少100 mmol/d的尿钠排泄量，收缩压降低3.7 mm Hg（2.35-5.05 mm Hg）（P
Objective.-To ascertain whether restriction of dietary sodium lowers blood pressure in hypertensive and normotensive individuals.Data Sources.-An English-language computerized literature search, restricted to human studies with Medical Subject Heading terms, ''hypertension,'' ''blood pressure,'' ''vascular resistance,'' ''sodium and dietary,'' ''diet and sodium restricted, ''sodium chloride,'' ''clinical trial,'' ''randomized controlled trial,'' and ''prospective studies,'' was conducted. Bibliographies of review articles and personal files were also searched.Trial Selection.-Trials that had randomized allocation to control and dietary sodium intervention groups, monitored by timed sodium excretion, with outcome measures of both systolic and diastolic blood pressure were selected by blinded review of the methods section.Data Extraction.-Two observers extracted data independently, using purpose-designed forms, and discrepancies were resolved by discussion.Data Synthesis.-The 56 trials that met our inclusion criteria showed significant heterogeneity. Publication bias was also evident. The mean reduction (95% confidence interval) in daily urinary sodium excretion, a proxy measure of dietary sodium intake, was 95 mmol/d (71-119 mmol/d) in 28 trials with 1131 hypertensive subjects and 125 mmol/d (95-156 mmol/d) in 28 trials with 2374 normotensive subjects. After adjustment for measurement error of urinary sodium excretion, the decrease in blood pressure for a 100-mmol/d reduction in daily sodium excretion was 3.7 mm Hg (2.35-5.05 mm Hg) for systolic (P