Myelodysplastic syndrome and autoimmunity: a case report of an unusual presentation of myelodysplastic syndrome.
Myelodysplastic syndrome and autoimmunity: a case report of an unusual presentation of myelodysplastic syndrome.
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DOI：
10.1155/2011/560106
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发表时间：
2011
影响因子：
0.7
通讯作者：
Smith H
中科院分区：
文献类型：
--
作者：
Merrill AL;Smith H
骨髓增生异常综合征（MDS）通常表现为无症状或有症状的血细胞减少。然而，与MDS相关的自身免疫现象已在几个病例报告和病例系列中得到很好的描述。通常，这些自身免疫现象采取血管炎、关节炎、结缔组织疾病、肺浸润或风湿性多肌痛的形式。我们介绍了一例MDS（核型46，XX，+1，der（1;7）（q10;p10）[20]，进化为额外的8三体克隆）和一种新的自身免疫性疾病谱，包括急性化脓性和机化性肺炎（AFOP）和泪腺假瘤。
Myelodysplastic syndrome (MDS) commonly presents asymptomatically or with symptomatic cytopenias. However, autoimmune phenomena in association with MDS have been well described in several case reports and case series. Typically, these autoimmune phenomena take the form of vasculitides, arthritis, connective tissue diseases, pulmonary infiltrates, or polymyalgia rheumatica. We present the case of a woman with MDS (karyotype 46,XX,+1,der(1;7)(q10;p10)[20], that evolved with an additional trisomy 8 clone) and a novel spectrum of autoimmune diseases including acute fibrinous and organizing pneumonia (AFOP) and lacrimal gland pseudotumor.