Effects of elevated plasma noradrenaline concentration on the immune system in humans
Effects of elevated plasma noradrenaline concentration on the immune system in humans
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DOI：
10.1007/s004210050479
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发表时间：
1998-12-01
期刊：
影响因子：
--
通讯作者：
Pedersen, BK
中科院分区：
文献类型：
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作者：
Kappel, M;Poulsen, TD;Pedersen, BK
本研究旨在验证这样一种假设，即血浆去甲肾上腺素浓度升高有助于运动诱导的自然杀伤(NK)细胞活性和百分比以及白细胞浓度的调节。在一项单盲、对照、交叉研究中，8名健康男性接受了去甲肾上腺素的ih注射，血浆去甲肾上腺素浓度与以前在自行车运动中观察到的去甲肾上腺素浓度(1小时最大摄氧量的75%)相当(增加了20倍)。去甲肾上腺素可提高未刺激、IL-2和干扰素-a刺激后的NK细胞活性和CD16+细胞百分率。然而，每个CD16+细胞的自然裂解活性没有改变。中性粒细胞、淋巴细胞和CD16+细胞浓度在输液过程中升高。中性粒细胞浓度在输注后2小时仍维持在较高水平，此时淋巴细胞计数恢复正常。这些结果与运动模型中的结果相当，提示极限运动时血浆去甲肾上腺素浓度升高可能参与了运动诱导的免疫变化。
This study was designed to test the hypothesis that elevated plasma noradrenaline concentrations contribute to the exercise-induced modulation of the activity and percentage of the natural killer (NK) cells, and the leucocyte concentration. In a single blind, controlled, cross-over study, eight healthy men had noradrenaline infused for Ih and achieved plasma noradrenaline concentrations comparable (20-fold increment) to those previously observed in cycle ergometer exercise (75% of maximal oxygen uptake for 1 h). The noradrenaline infusion increased the unstimulated, the interleukin-2 and interferon-a stimulated NK cell activity, and the percentage of CD16+ cells. The natural lytic activity per CD16+ cell however, did not change. The concentration of neutrophils, lymphocytes and CD16+ cells increased during the infusion. The neutrophil concentration remained elevated 2 h after infusion, at which time the lymphocyte count was back to normal. These results are comparable with the effects in the exercise model, and it is suggested that the augmented plasma noradrenaline concentrations, seen during extreme exercise, may participate in the exercise-induced immune changes.