Mesoporous silica nanoparticles functionalized with an oxygen-sensing probe for cell photodynamic therapy: potential cancer theranostics
Mesoporous silica nanoparticles functionalized with an oxygen-sensing probe for cell photodynamic therapy: potential cancer theranostics
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DOI：
10.1039/b816636f
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发表时间：
2009-01-01
影响因子：
--
通讯作者：
Lo, Leu-Wei
中科院分区：
文献类型：
--
作者：
Cheng, Shih-Hsun;Lee, Chia-Hung;Lo, Leu-Wei
报道了钯卟啉修饰介孔二氧化硅纳米粒子用于肿瘤细胞光动力治疗的研究。复合平台MSN-PdTPP将Pd-卟啉的作用从常规用作氧传感/成像（诊断）的磷光探针扩展到用于癌细胞光疗（治疗）的新型纳米光敏剂。还评估了MSN-PdTPP在MDA-MB-231乳腺癌细胞的光疗治疗中的效用，这表明它是一种有前途的癌症治疗诊断平台。
Functionalization of mesoporous silica nanoparticles (MSNs) with Pd-porphyrins for cancer cell photodynamic therapy is reported. The composite platform, MSN-PdTPP, expands the role of Pd-porphyrins from their routine use as phosphorescence probes for oxygen sensing/imaging (diagnostics) to that of novel nano-photosensitizers for cancer cell phototherapy (therapeutics). The utility of MSN-PdTPP in the phototherapeutic treatment of MDA-MB-231 breast cancer cells is also evaluated, suggesting it is a promising cancer theranostic platform.