CXCL12 genetic variants as prognostic markers in nasopharyngeal carcinoma.
CXCL12 genetic variants as prognostic markers in nasopharyngeal carcinoma.
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CXCL12 基因变异作为鼻咽癌的预后标志物。
DOI：
10.2147/ott.s90430
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发表时间：
2015
影响因子：
4
通讯作者：
Ma J
中科院分区：
文献类型：
--
作者：
Chen R;Xu Y;Du X;Liu N;Li Y;He Q;Tang L;Mao Y;Sun Y;Chen L;Ma J
趋化因子受体4/趋化因子配体12（CXCR 4/CXCL 12）轴在肿瘤的发生、转移和复发中起重要作用。它的单核苷酸多态性（SNP）与几种类型癌症的患者生存相关。然而，SNPs在鼻咽癌（NPC）中的预后价值尚未得到充分研究。本回顾性研究评估了222例新诊断的NPC患者中CXCR 4 rs 2228014和CXCL 12 rs 1801157多态性与患者预后的关系。分析发现SNPs和临床病理因素之间没有显著相关性。然而，单变量分析显示N分类、临床分期和CXCL 12 rs 1801157多态性与无远处转移生存期（分别为P=0.018、0.028和0.013）和无进展生存期（分别为P=0.007、0.046和0.021）显著相关。在调整临床病理因素后，多变量分析确定CXCL 12 rs 1801157是无远处转移生存期和无进展生存期的独立预后因素（风险比：3.332; 95%置信区间：1.597-6.949; P=0.001和风险比：2.665; 95%置信区间：1.387-5.119; P=0.003）。提示CXCL 12 rs 1801157 AA基因型可能是影响鼻咽癌患者预后的一个潜在因素。
The chemokine receptor 4/chemokine ligand 12 (CXCR4/CXCL12) axis plays an important role in tumorigenesis, metastasis, and recurrence of tumors. Its single nucleotide polymorphisms (SNPs) are associated with patient survival in several types of cancer. However, the prognostic value of SNPs in nasopharyngeal carcinoma (NPC) has not been fully investigated. This retrospective study assessed the relationships between CXCR4 rs2228014 and CXCL12 rs1801157 polymorphisms and patient outcome in 222 patients newly diagnosed with NPC. The analysis found no significant correlation between the presence of both SNPs and clinicopathological factors. However, univariate analysis showed that N classification, clinical stage, and the CXCL12 rs1801157 polymorphism were significantly associated with distant metastasis-free survival (P=0.018, 0.028, and 0.013, respectively) and progression-free survival (P=0.007, 0.046, and 0.021, respectively). After adjusting clinicopathological factors, multivariate analysis identified CXCL12 rs1801157 as an independent prognostic factor for distant metastasis-free survival and progression-free survival (hazard ratio: 3.332; 95% confidence interval: 1.597–6.949; P=0.001 and hazard ratio: 2.665 95% confidence interval: 1.387–5.119; P=0.003, respectively). Our results suggest that CXCL12 rs1801157 AA genotype might serve as a potential prognostic factor in patients with NPC.