Negative regulator NLRC3: Its potential role and regulatory mechanism in immune response and immune-related diseases.
Negative regulator NLRC3: Its potential role and regulatory mechanism in immune response and immune-related diseases.
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负调节因子NLRC3：其在免疫反应和免疫相关疾病中的潜在作用和调节机制。
DOI：
10.3389/fimmu.2022.1012459
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
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作者：
NLRC3 是模式识别受体核苷酸结合寡聚化结构域 (NOD) 样受体 (NLR) 家族的成员，在调节免疫细胞的激活中发挥着关键的调节作用。在巨噬细胞中，NLRC3 抑制 NF-κB 信号通路、STING/TBK1 信号通路的激活以及炎症小体的形成。在T细胞免疫反应的背景下，NLRC3通过调节树突状细胞的功能并直接影响T细胞的功能来阻止T细胞的激活。与其他模式识别受体不同，NLRC3与调节活性的关系比病原体识别更为密切，它影响细胞的命运，例如阻止增殖、促进细胞凋亡和抑制细胞焦亡。 NLRC3调控的这些细胞功能参与多种疾病的发生发展过程，如传染病、无菌性炎症性疾病、癌症等。然而，其在免疫反应和免疫相关疾病中的特点、功能和调节机制尚未得到充分阐明。在这篇综述中，我们从分子机制、细胞功能等多个不同层面阐述了NLRC3在免疫相关疾病中的潜在作用。
NLRC3 is a member of the pattern recognition receptors nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) family, and plays a pivotal regulatory role in modulating the activation of immune cells. In macrophages, NLRC3 inhibits the activation of the NF-κB signaling pathway, the STING/TBK1 signaling pathway, and the formation of the inflammasome. In the context of T cells immune response, NLRC3 prevents the activation of T cells by regulating the function of dendritic cells and directly influencing the function of T cells. Different from other pattern recognition receptors, NLRC3 is more closely associated with regulatory activity than pathogens recognition, it influences the fates of cells, for example, prevents proliferation, promotes apoptosis and inhibits pyroptosis. These cellular functions regulated by NLRC3 are involved in the development processes of a variety of diseases, such as infectious disease, sterile inflammatory diseases, and cancer. However, its characteristics, function and regulatory mechanism in immune response and immune-related diseases have not been addressed fully. In this review, we elaborate the potential roles of NLRC3 from several different levels, include molecular mechanism, cellular functions in the immune-related diseases.