Impairment of cardiopulmonary baroreflexes in Dahl salt-sensitive rats fed low salt.
Impairment of cardiopulmonary baroreflexes in Dahl salt-sensitive rats fed low salt.
复制标题
喂低盐的达尔盐敏感大鼠心肺压力反射受损。
DOI：
10.1152/ajpheart.1984.247.1.h119
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
A. Mark
中科院分区：
文献类型：
--
作者：
A. Ferrari;F. Gordon;A. Mark
Dahl敏感（DS）大鼠的高血压与神经循环功能障碍有关。本研究验证了高血压前DS大鼠心肺压力感受性反射功能受损的假设。该研究在喂食低盐饮食的DS和Dahl抗性（DR）大鼠中进行。动脉压力感受器失神经支配。交感神经活动记录从内脏神经刺激心肺压力感受器与容量扩张（静脉右旋糖酐）。DS大鼠的静息平均动脉压平均为93 +/- 6（SE），DR大鼠为98 +/- 5 mmHg。DR大鼠的静息左心室舒张末期压（LVEDP）为13.5 +/- 1.0 in/DS vs. 11.4 +/- 0.9 mmHg。与DR大鼠相比，用等量右旋糖酐进行容量扩张导致DS（+13 +/-1 mmHg）的LVEDP增加幅度大于DR（+10 +/- 1 mmHg），但DS对交感神经活性的抑制程度小于DR大鼠（-40 +/- 4 vs. -50 +/- 2%）。心脏压力反射增益计算为交感神经活性抑制百分比除以LVEDP增加，DS为-3.2 +/- 0.2，DR大鼠为-4.9 +/- 0.6%/mmHg。对右旋糖酐的反射反应被迷走神经切断术消除。容量扩张也引起平均动脉压升高。迷走神经切断术前，DS组的这些压力大于DR组（分别为+43 +/- 4和+28 +/- 5 mmHg），但迷走神经切断术后，两组的压力相似。DS和DR大鼠左心房的扩张性（Δ容积/Δ压力）相似。我们的结论是，高血压前DS大鼠的心肺压力感受性反射受损。（250字处删节）
Abnormalities in neural circulatory control contribute to salt-induced hypertension in Dahl sensitive (DS) rats. This study tested the hypothesis that there is impairment in cardiopulmonary baroreflex function in prehypertensive DS rats. The study was performed in DS and Dahl resistant (DR) rats fed low-salt diet. Arterial baroreceptors were denervated. Sympathetic activity was recorded from the splanchnic nerve during stimulation of cardiopulmonary baroreceptors with volume expansion (iv dextran). Resting mean arterial pressure averaged 93 +/- 6 (SE) in DS vs. 98 +/- 5 mmHg in DR rats. Resting left ventricular end-diastolic pressure (LVEDP) was 13.5 +/- 1.0 in/DS vs. 11.4 +/- 0.9 mmHg in DR rats. Volume expansion with the same amount of dextran caused greater increases in LVEDP in DS (+13 +/- 1 mmHg) than DR (+10 +/- 1 mmHg) but less inhibition of sympathetic activity (-40 +/- 4 vs. -50 +/- 2%) in DS compared with DR rats, respectively. Cardiopulmonary baroreflex gain calculated as percent inhibition of sympathetic activity divided by increases in LVEDP was -3.2 +/- 0.2 in DS vs. -4.9 +/- 0.6%/mmHg in DR rats. Reflex responses to dextran were abolished by vagotomy. Volume expansion also induced increases in mean arterial pressure. These were/greater in DS than DR rats (+43 +/- 4 vs. +28 +/- 5 mmHg, respectively) before vagotomy but were similar in the two groups after vagotomy. The distensibility (delta volume/delta pressure) of the left atrium was similar in DS and DR rats. We conclude that prehypertensive DS rats have impairment of the cardiopulmonary baroreflex.(ABSTRACT TRUNCATED AT 250 WORDS)