Role of NPY and its receptor subtypes in foraging, food hoarding, and food intake by Siberian hamsters
Role of NPY and its receptor subtypes in foraging, food hoarding, and food intake by Siberian hamsters
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DOI：
10.1152/ajpregu.00853.2004
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发表时间：
2005-07-01
影响因子：
2.8
通讯作者：
Bartness, TJ
中科院分区：
文献类型：
--
作者：
Day, DE;Keen-Rhinehart, E;Bartness, TJ
禁食具有广泛的生理和行为影响，例如啮齿动物（包括西伯利亚仓鼠）中弓状核神经肽Y（NPY）基因表达的增加。禁食还刺激西伯利亚仓鼠的觅食和食物囤积（食欲摄食行为），但对食物摄入量（消耗性摄食行为）的影响相对较小。因此，我们测试了第三心室NPY Y1（[Pro（34）] NPY）或Y 5（[D-Trp（34）]NPY）受体激动剂对这些摄食行为的影响，使用基于轮跑的食物输送系统与模拟洞穴住房相结合。西伯利亚仓鼠有1）没有运行轮访问和免费的食物，2）运行轮访问和免费的食物，或3）觅食要求（10或50转/颗粒）。NPY（1.76 nmol）仅在注射后的前4小时内刺激摄食（类似于200- 1，000%），主要在有觅食要求的仓鼠中。Y1受体激动剂显著增加食物囤积（250- 1，000%），增加觅食以及车轮运行本身，对食物摄入量的影响相对较小（< 250%）。与NPY不同，Y 5激动剂显著增加了食物摄入量，尤其是在觅食动物中（类似于225-800%），略微增加了食物囤积（250-500%），并刺激了注射后4 - 24 h的觅食和车轮运行，随着时间的推移，获得的颗粒分布有利于进食而不是囤积。在所有治疗中，食物囤积在注射后早期占主导地位，而食物摄入往往在注射后较晚。总的来说，神经肽Y刺激西伯利亚仓鼠的食欲和消耗性摄食行为，涉及Y1/Y 5受体，食物囤积和觅食/车轮运行（食欲）更多地涉及Y1受体和食物摄入（消耗性）与Y 5受体。
Fasting has widespread physiological and behavioral effects such as increases in arcuate nucleus neuropeptide Y (NPY) gene expression in rodents, including Siberian hamsters. Fasting also stimulates foraging and food hoarding (appetitive ingestive behaviors) by Siberian hamsters but does relatively little to change food intake (consummatory ingestive behavior). Therefore, we tested the effects of third ventricular NPY Y1 ([Pro(34)] NPY) or Y5 ([D-Trp(34)]NPY) receptor agonists on these ingestive behaviors using a wheel running-based food delivery system coupled with simulated burrow housing. Siberian hamsters had 1) no running wheel access and free food, 2) running wheel access and free food, or 3) foraging requirements (10 or 50 revolutions/pellet). NPY (1.76 nmol) stimulated food intake only during the first 4 h postinjection (similar to 200-1,000%) and mostly in hamsters with a foraging requirement. The Y1 receptor agonist markedly increased food hoarding (250-1,000%), increased foraging as well as wheel running per se, and had relatively little effect on food intake (< 250%). Unlike NPY, the Y5 agonist significantly increased food intake, especially in foraging animals (similar to 225-800%), marginally increased food hoarding (250-500%), and stimulated foraging and wheel running 4 - 24 h postinjection, with the distribution of earned pellets favoring eating versus hoarding across time. Across treatments, food hoarding predominated early postinjection, whereas food intake tended to do so later. Collectively, NPY stimulated both appetitive and consummatory ingestive behaviors in Siberian hamsters involving Y1/Y5 receptors, with food hoarding and foraging/wheel running (appetitive) more involved with Y1 receptors and food intake (consummatory) with Y5 receptors.