A long DNA segment in a linear nanoscale Paul trap.

A long DNA segment in a linear nanoscale Paul trap.
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DOI:
10.1088/0957-4484/21/1/015103
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发表时间:
2010-01-08
期刊:
影响因子:
3.5
通讯作者:
Krstic PS
Krstic PS
中科院分区:
材料科学3区
文献类型:
--
作者:
Joseph S;Guan W;Reed MA;Krstic PS

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我们研究了线性分布线电荷的动力学,例如真空中纳米级线性 2D Paul 陷阱中的单链 DNA。使用分子动力学模拟,我们表明,在明确定义的稳定性参数范围内,线电荷可以被有效地捕获在陷阱中。我们针对不同的陷阱参数研究了 (i) 柔性有界带电珠串,以及 (ii) 可变长度的 ssDNA 聚合物。线电荷在移动时会经历振荡或旋转,具体取决于其初始角度、质心位置和速度。带电珠子的强键合线的稳定区域与具有相同电荷质量比的单个离子的稳定区域相似。长达 40 纳米的单链 DNA 在保罗陷阱中不会折叠或卷曲,但可以绕质心旋转。为了防止旋转,我们证明轴向拉伸场可以有效防止旋转并增加限制稳定性。
We study the dynamics of a linear distributed line charge such as a single stranded DNA in a nanoscale, linear 2D Paul trap in vacuum. Using molecular dynamics simulations we show that a line charge can be trapped effectively in the trap within well defined range of stability parameters. We investigated (i) a flexible bounded string of charged beads, and (ii) a ssDNA polymer of variable length, for various trap parameters. A line charge undergoes oscillations or rotations as it moves depending on its initial angle, position of the center-of-mass and velocity. The stability region for a strongly bonded line of charged beads is similar to that of a single ion with the same charge over mass ratio. A single stranded DNA, as long as 40nm, does not fold or curl in the Paul trap, but could undergo rotations about the center of mass. To prevent the rotations, we show that a stretching field in the axial direction can effectively prevent the rotations and increase the confinement stability.
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