Risk of Second Primary Malignancies Based on the Histological Subtypes of Colorectal Cancer.
Risk of Second Primary Malignancies Based on the Histological Subtypes of Colorectal Cancer.
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基于结直肠癌组织学亚型的第二原发恶性肿瘤的风险
DOI：
10.3389/fonc.2021.650937
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发表时间：
2021
影响因子：
4.7
通讯作者：
Chu X
中科院分区：
文献类型：
--
作者：
Wu M;Huang M;He C;Chen C;Li H;Wang J;Liu M;Fu G;Lei Z;Chu X
背景资料：以前的研究已经揭示了结直肠癌（CRC）后第二原发恶性肿瘤（SPM）的风险增加;然而，没有以前的研究已经量化了基于第一原发CRC的组织学亚型的SPM风险差异。研究方法：2000年至2011年间诊断为原发性CRC的患者来自监测、流行病学和最终结果癌症登记处。患者被分为三个队列：经典腺癌（CA），粘液腺癌（MA）和印戒细胞癌（SRCC）。计算标准化发病率比率以评估患者中SPM的风险。结果：三种组织学亚型的结直肠癌患者中SPM的总体风险显著高于一般人群。SRCC患者发生食管癌的危险性显著增加。在三种组织学亚型中，小肠癌、结肠直肠癌和子宫体癌的风险较高，SRCC中观察到的风险最高，其次是MA。仅在CA患者中观察到第二次胃癌、子宫癌、膀胱癌、肾癌和甲状腺癌的风险增加，而第二次肾盂癌的风险增加仅限于MA患者。此外，无论临床病理因素如何，CA患者中SPM的高总体风险持续存在。手术联合化疗后，CA患者比单纯手术治疗者更容易发生第二次小肠癌、结肠癌和直肠癌。直肠癌患者手术联合放疗的第二次前列腺癌风险低于单纯手术治疗的患者。结论：目前的研究表明，CRC后发生SPM的风险因首次原发性CRC的组织学亚型而异。虽然SPM风险模式的机制尚不清楚，但该研究为基于CRC组织学亚型的未来癌症监测提供了见解。
Background: Previous studies have revealed an increased risk of second primary malignancies (SPMs) after colorectal cancer (CRC); however, no previous investigation has quantified differences in the risk of SPMs based on the histological subtypes of first primary CRC. Methods: Patients diagnosed with first primary CRC between 2000 and 2011 were identified from the Surveillance, Epidemiology, and End Results cancer registries. The patients were divided into three cohorts: classical adenocarcinoma (CA), mucinous adenocarcinoma (MA), and signet-ring cell carcinoma (SRCC). Standardized incidence ratios were calculated to assess the risk of SPMs among the patients. Results: Overall risk of SPMs was significantly higher among patients with three histological subtypes of CRC than in the general population. The risk of esophagus cancer was significantly increased in SRCC. The risk of small intestine, colon and rectum, and corpus uteri cancers was high in three histological subtypes, with the highest risk observed in SRCC, followed by MA. Increased risks of second stomach, uterus, urinary bladder, kidney, and thyroid cancers were only observed in CA patients, while increased risk of second renal pelvis cancer was limited to MA patients. Furthermore, the high overall risk of SPMs in CA patients persisted regardless of clinicopathological factors. After surgery combined with chemotherapy treatment, CA patients were more prone to developing second small intestine, colon and rectum cancers than those treated with surgery only. A lower second prostate cancer risk was observed in rectal CA patients treated with surgery combined with radiotherapy than in patients treated with surgery only. Conclusion: The present study revealed that the risk of developing SPMs after CRC varied based on the histological subtypes of the first primary CRC. Although the mechanisms underlying the observed patterns of SPM risk remain unknown, the study provided insights into future cancer surveillance based on the histological subtypes of CRC.
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影响因子：
3.7
作者：
Hyngstrom JR;Hu CY;Xing Y;You YN;Feig BW;Skibber JM;Rodriguez-Bigas MA;Cormier JN;Chang GJ
通讯作者：
Chang GJ
影响因子：
9
作者：
Nitsche U;Zimmermann A;Späth C;Müller T;Maak M;Schuster T;Slotta-Huspenina J;Käser SA;Michalski CW;Janssen KP;Friess H;Rosenberg R;Bader FG
通讯作者：
Bader FG
影响因子：
5.8
作者：
Jia, Huixun;Li, Qingguo;Wu, Zhenyu
通讯作者：
Wu, Zhenyu
影响因子：
8.8
作者：
Catalano, V.;Loupakis, F.;Graziano, F.;Torresi, U.;Bisonni, R.;Mari, D.;Fornaro, L.;Baldelli, A. M.;Giordani, P.;Rossi, D.;Alessandroni, P.;Giustini, L.;Silva, R. R.;Falcone, A.;D'Emidio, S.;Fedeli, S. L.
通讯作者：
Fedeli, S. L.
影响因子：
24.5
作者：
Møller P;Seppälä T;Bernstein I;Holinski-Feder E;Sala P;Evans DG;Lindblom A;Macrae F;Blanco I;Sijmons R;Jeffries J;Vasen H;Burn J;Nakken S;Hovig E;Rødland EA;Tharmaratnam K;de Vos Tot Nederveen Cappel WH;Hill J;Wijnen J;Green K;Lalloo F;Sunde L;Mints M;Bertario L;Pineda M;Navarro M;Morak M;Renkonen-Sinisalo L;Frayling IM;Plazzer JP;Pylvanainen K;Sampson JR;Capella G;Mecklin JP;Möslein G;Mallorca Group (http://mallorca-group.eu)
通讯作者：
Mallorca Group (http://mallorca-group.eu)