Prognostic value of volumetric parameters of 18F-FDG PET in non-small-cell lung cancer: a meta-analysis
Prognostic value of volumetric parameters of 18F-FDG PET in non-small-cell lung cancer: a meta-analysis
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DOI：
10.1007/s00259-014-2903-7
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发表时间：
2015-02-01
影响因子：
9.1
通讯作者：
Lee, Dong Soo
中科院分区：
文献类型：
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作者：
Im, Hyung-Jun;Pak, Kyoungjune;Lee, Dong Soo
目的 我们对 F-18-FDG PET 体积参数的文献进行全面系统回顾，并对肺癌患者代谢肿瘤体积（MTV）和总病灶糖酵解（TLG）的预后价值进行荟萃分析。方法使用关键词“正电子发射断层扫描（PET）”、“肺癌”和“体积”在 MEDLINE 和 EMBASE 中进行系统检索。纳入标准为： F-18-FDG PET 用作初始成像工具；研究仅限于非小细胞肺癌（NSCLC）；肺癌体积测量； PET扫描前未接受过手术、化疗或放疗的患者；以及报告生存数据的研究。无事件生存期和总生存期作为结果进行评估。 MTV 和 TLG 对生存的影响是根据风险比 (HR) 效应大小来衡量的。使用 Review Manager 5.2 分析每项研究的数据。 结果 分析了 13 项符合条件的研究，包括 1,581 名患者。 MTV 高的患者预后较差，HR 为 2.71（95% CI 1.82 - 4.02，p
Purpose We conducted a comprehensive systematic review of the literature on volumetric parameters from F-18-FDG PET and a meta-analysis of the prognostic value of metabolic tumour volume (MTV) and total lesion glycolysis (TLG) in patients with lung cancer.Methods A systematic search of MEDLINE and EMBASE was performed using the keywords "positron emission tomography (PET)", "lung cancer", and "volume". Inclusion criteria were: F-18-FDG PET used as an initial imaging tool; studies limited to non-small-cell lung cancer (NSCLC); volume measurement of lung cancer; patients who had not undergone surgery, chemotherapy, or radiotherapy before the PET scan; and studies that reported survival data. Event-free survival and overall survival were evaluated as outcomes. The impact of MTV and TLG on survival was measured in terms of the hazard ratio (HR) effect size. Data from each study were analysed using Review Manager 5.2.Results Thirteen eligible studies including 1,581 patients were analysed. Patients with high MTV showed a worse prognosis with an HR of 2.71 (95 % CI 1.82 - 4.02, p