Imaging mass spectrometry: challenges in visualization of drug distribution in solid tumors
Imaging mass spectrometry: challenges in visualization of drug distribution in solid tumors
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DOI：
10.1016/j.coph.2013.06.003
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发表时间：
2013-10-01
影响因子：
4
通讯作者：
Davoli, Enrico
中科院分区：
文献类型：
--
作者：
Morosi, Lavinia;Zucchetti, Massimo;Davoli, Enrico
质谱成像（MSI）是一种新兴的技术，它允许直接在生物组织中的二维空间中对药物和代谢物的分布进行分子可视化。肿瘤内药物分布的成像是支持改善抗癌药物渗透并因此改善化疗结果的策略的重要工具。MSI与其他成像技术相比具有一些优势，即全身放射自显影，正电子发射断层扫描或显微镜成像。它是一种无标记的技术，具有更好的特异性，并提供了可能性，联合收割机组织学数据与MS的，并同时可视化的生物标志物的分布与肿瘤异质性。本文综述了MSI在肿瘤组织中抗癌药物分布研究中的应用。此外，我们将注意力集中在技术限制和与此技术有关的未来前景上。
Mass spectrometry imaging (MSI) is an emerging technique that allows molecular visualization of the distribution of drugs and metabolites in a two-dimensional space directly in biological tissues. Imaging drug distribution inside a tumor is an important tool to support strategies to improve penetration of anticancer drugs and consequently the outcome of chemotherapy. MSI has some advantages in comparison to other imaging techniques, that is, whole body autoradiography, positron emission tomography or microscopy imaging. It is a label-free technique with better specificity and provides the possibility to combine histological data with MS ones and to visualize simultaneously the distribution of biomarkers in relation to tumor heterogeneity. We overview here publications on MSI applied to studies of the distribution of anticancer agents in tumor tissue. In addition, we focused our attention on technical limitations and future perspectives pertaining to this technique.