Syntheses of stable bacteriochlorophyll-a derivatives as potential photosensitizers for photodynamic therapy
Syntheses of stable bacteriochlorophyll-a derivatives as potential photosensitizers for photodynamic therapy
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DOI：
10.1016/0040-4039(96)01346-9
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发表时间：
1996-09-02
影响因子：
1.8
通讯作者：
Pandey, RK
中科院分区：
文献类型：
--
作者：
Kozyrev, AN;Zheng, G;Pandey, RK
Rb中不稳定细菌叶绿素a转化的新方法sphaeroides转化为稳定的菌绿素。通过分子内碱催化的环化反应从相关的环状异酰亚胺或酰胺类似物获得环状酰亚胺衍生物。大多数新的细菌绿素在796-822 nm范围内具有长波长吸收。在初步筛选中，异酰亚胺类似物已显示出用于光动力疗法治疗癌症的有希望的体内光敏活性。版权所有（C）1996 Elsevier Science Ltd
New methods for conversion of unstable bacteriochlorophyll-a present in Rb. sphaeroides into stable bacteriochlorins are presented. Cyclic imide derivatives from related cyclic isoimide or amide analogs are obtained by intramolecular base catalyzed cyclization. Most of the new bacteriochlorins have long wavelength absorptions in the range of 796-822 nm In preliminary screening, the isoimide analogs have shown promising in vivo photosensitizing activity for the treament of cancer by photodynamic therapy. Copyright (C) 1996 Elsevier Science Ltd