Odd-skipped related 2 regulates genes related to proliferation and development.
Odd-skipped related 2 regulates genes related to proliferation and development.
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DOI：
10.1016/j.bbrc.2010.06.054
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发表时间：
2010-07
影响因子：
3.1
通讯作者：
S. Kawai;Y. Abiko;A. Amano
中科院分区：
文献类型：
--
作者：
S. Kawai;Y. Abiko;A. Amano
细胞增殖是染色体在一个细胞中复制并均等地分裂成两个子细胞的生物学过程。我们先前的研究结果表明Osr2在表观遗传调控下对细胞的静止和增殖起重要作用。然而，Osr2用于建立和维持增殖的机制尚不清楚。为了研究Osr2在细胞增殖中的功能作用，我们在腺病毒诱导的Osr2过表达以及Osr2 siRNA敲低后使用微阵列分析分析了其下游靶基因，这表明Osr2调节参与增殖和细胞周期以及发育的众多基因。另外的增殖测定也表明Osr2可能起引起细胞增殖的作用。总之，这些结果表明Osr2在增殖和发育中起着重要作用。
Cell proliferation is a biological process in which chromosomes replicate in one cell and equally divide into two daughter cells. Our previous findings suggested that Odd-skipped related 2 (Osr2) plays an important role in cellular quiescence and proliferation under epigenetic regulation. However, the mechanism used by Osr2 to establish and maintain proliferation is unknown. To examine the functional role of Osr2 in cell proliferation, we analyzed its downstream target genes using microarray analysis following adenovirus-induced overexpression of Osr2 as well as knockdown with Osr2 siRNA, which showed that Osr2 regulates a multitude of genes involved in proliferation and the cell cycle, as well as development. Additional proliferation assays also indicated that Osr2 likely functions to elicit cell proliferation. Together, these results suggest that Osr2 plays important roles in proliferation and development.