Impact of oral contraceptive pill use on premenstrual mood: Predictors of improvement and deterioration
Impact of oral contraceptive pill use on premenstrual mood: Predictors of improvement and deterioration
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DOI：
10.1016/s0002-9378(03)00927-x
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发表时间：
2003-12-01
影响因子：
9.8
通讯作者：
Harlow, BL
中科院分区：
文献类型：
--
作者：
Joffe, H;Cohen, LS;Harlow, BL
目的：本研究的目的是评估口服避孕药使用对经前情绪障碍恶化和改善的危险因素。研究设计：在马萨诸塞州一个以社区为基础的队列中，采用巢式病例对照研究中的逻辑回归分析了口服避孕药使用对经前情绪有害和有益影响的预测因素。在658名使用口服避孕药的妇女中，16.3%的妇女报告口服避孕药相关的经前情绪恶化，12.3%的妇女报告经前情绪改善。在调整后的模型中，先前的抑郁是情绪恶化的唯一重要预测因素（比值比，2.0; 95% CI，1.1-3.8）;早发性经前情绪障碍和痛经是口服避孕药相关情绪改善的重要预测因素（比值比分别为3.1 [95% CI，1.9-5.2]和2.3 [95% CI，1.4-3.9]）。结论：口服避孕药对大多数妇女的经前情绪无影响。有抑郁症史的女性经前情绪最容易恶化，而早发性经前情绪障碍或痛经的女性经前情绪最容易改善。
OBJECTIVES: The purpose of this study was to estimate risk factors for the deterioration and improvement of premenstrual mood disturbance with oral contraceptive pill use.STUDY DESIGN: Predictors of the deleterious and beneficial effects of oral contraceptive pill use on premenstrual mood were analyzed with the use of logistic regression in a nested case-control study within a community-based cohort of 976 premenopausal women in Massachusetts.RESULTS: Of 658 women who were using oral contraceptive pills, 16.3% of the women reported oral contraceptive pill-related premenstrual mood deterioration, and 12.3% of the women reported premenstrual mood improvement. In adjusted models, previous depression was the only significant predictor of mood deterioration (odds ratio, 2.0; 95% CI, 1.1-3.8); early-onset premenstrual mood disturbance and dysmenorrhea were significant predictors of oral contraceptive pill-related mood improvement (odds ratio, 3.1 [95% CI, 1.9-5.2] and odds ratio, 2.3 [95% CI, 1.4-3.9], respectively).CONCLUSION: Oral contraceptive pills do not influence premenstrual mood in most women. Premenstrual mood is most likely to deteriorate in women with a history of depression and to improve in women with early-onset premenstrual mood disturbance or dysmenorrhea.