Nedd4 and Nedd4-2: Ubiquitin ligases at work in the neuron
Nedd4 and Nedd4-2: Ubiquitin ligases at work in the neuron
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DOI：
10.1016/j.biocel.2012.12.006
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发表时间：
2013-03-01
影响因子：
4
通讯作者：
Poronnik, Philip
中科院分区：
文献类型：
--
作者：
Donovan, Prudence;Poronnik, Philip
泛素连接酶Nedd 4家族对蛋白质的泛素化是蛋白质运输和降解的重要机制，并提供了严格的时空调控。泛素化作为神经元发育和脑内稳态调节的中枢机制正得到越来越多的认可。这篇综述将集中在Nedd 4和Nedd 4 -2 E3泛素连接酶，涉及越来越多的神经元蛋白质-蛋白质相互作用。了解Nedd 4和Nedd 4 -2在调节大脑关键功能中的作用，不仅在协调降解事件中，而且在蛋白质运输中，都为泛素化信号提供了新的线索。此外，神经元中几个新的Nedd 4/4-2靶点的描述正在改变我们概念化神经元如何维持正常功能以及如何在疾病中改变的方式。(c)2013爱思唯尔有限公司保留所有权利。
Ubiquitination of proteins by the Nedd4 family of ubiquitin ligases is a significant mechanism in protein trafficking and degradation and provides for tight spatiotemporal regulation. Ubiquitination is gaining increasing recognition as a central mechanism underpinning the regulation of neuronal development and homeostasis in the brain. This review will focus on the Nedd4 and Nedd4-2 E3 ubiquitin ligases that are implicated in an increasing number of neuronal protein-protein interactions. Understanding of the contribution of Nedd4 and Nedd4-2 in regulating key functions in the brain is shedding new light on the ubiquitination signal not only in orchestrating degradation events but also in protein trafficking. Furthermore, the description of several novel Nedd4/4-2 targets in neurons is changing the way we conceptualize how neurons maintain normal function and how this is altered in disease. (c) 2013 Elsevier Ltd. All rights reserved.