Human Toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy
Human Toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy
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DOI：
10.1097/01.inf.0000195595.22547.fe
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发表时间：
2006-01-01
影响因子：
3.6
通讯作者：
Mannhalter, C
中科院分区：
文献类型：
--
作者：
Faber, J;Meyer, CU;Mannhalter, C
Toll样受体4（TLR4）是有效识别细菌感染所必需的。我们通过等位基因特异性真实的时间聚合酶链反应和直接测序研究了197例脑膜炎球菌病患者和214例健康对照者的2种TLR4突变（ASP（299）Gly和Thr（399）Ile）与脑膜炎球菌病之间的关联。虽然等位基因频率在总体患者人群中并不高，但在40例年龄小于12个月的患者中观察到显著更高的频率（P = 0.007）。我们的结论是TLR4突变代表了该年龄组脑膜炎球菌病的危险因素。
Toll-like receptor 4 (TLR4) is required for efficient recognition of bacterial infections. We investigated an association between 2 TLR4 mutations (ASP(299)Gly and Thr(399)Ile) and meningococcal disease in 197 patients and 214 healthy controls by allele-specific real time polymerase chain reaction and direct sequencing. Although the allele frequency was not higher in the overall patient population, a significantly higher frequency in the 40 patients younger than 12 months of age (P = 0.007) was observed. We conclude that TLR4 mutations represent a risk factor for meningococcal disease in this age group.