Spinal-cord involvement in diabetic peripheral neuropathy
Spinal-cord involvement in diabetic peripheral neuropathy
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DOI：
10.1016/s0140-6736(00)05268-5
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发表时间：
2001-07-07
期刊：
影响因子：
168.9
通讯作者：
Tesfaye, S
中科院分区：
文献类型：
--
作者：
Eaton, SEM;Harris, ND;Tesfaye, S
糖尿病远端对称性多发性神经病（DSP）的发病机制知之甚少，但有一些证据表明，疾病的过程可能会超出周围神经。我们使用磁共振成像测量了有无DSP的糖尿病患者和健康对照组的脊髓横截面积。在c4/5和T3/4时，两组之间的脊髓面积存在显著差异（分别为p=0.004和p=0.033），与对照组相比，DSP组的脊髓面积较小（C4/5和T3/4分别为p=0.001和p=0.016）。这些结果表明，DSP是不是简单的周围神经疾病，并有大量的参与脊髓。
The pathogenesis of diabetic distal symmetrical polyneuropathy (DSP) is poorly understood but there is some evidence that the disease process might extend beyond peripheral nerves. We used magnetic-resonance imaging to measure spinal-cord cross-sectional area in diabetic patients with and without DSP and in healthy controls. There were significant differences in cord area between the groups at c4/5 and T3/4 (p=0.004 and p=0.033, respectively), with a smaller cord area in those with DSP compared with controls (p=0.001 and p=0.016 for C4/5 and T3/4, respectively). These results indicate that DSP is not simply a disease of the peripheral nerve and that there is substantial involvement of the spinal cord.