Binding potencies of 3 new 12 specific blockers to receptors in the ciliary processes and the possible relevance of these drugs to intraocular pressure control
Binding potencies of 3 new 12 specific blockers to receptors in the ciliary processes and the possible relevance of these drugs to intraocular pressure control
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3 种新的 12 种特异性阻断剂与睫状突受体的结合效力以及这些药物与眼压控制的可能相关性
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通讯作者：
Dr G. Tropc
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作者：
G. E. T. And;Barry CLARK2;Dr G. Tropc
用放射配体技术研究了3种新的12种阻断剂与睫状突受体的结合能力。研究的药物为IPS 339、ICI 118，551和Sandoz LI 32-468。这些药物的效力顺序为IPS 339>Sandoz LI 32-468> ICI 18，551。这些药物的12个解离常数（KD）分别为0-90 nM、6和60 nM以及55 nM。这些结果与其他肾上腺素能药物，包括噻吗洛尔。局部12阻滞剂在青光眼的潜在作用进行了讨论。
SUMMARY The binding potencies of 3 new 12 blocking drugs to receptors in the ciliary processes were studied by means of radioligand techniques. The drugs studied were IPS339, ICI 118,551, and Sandoz LI 32-468. The order of potency of these drugs was IPS339>Sandoz LI 32-468> ICI1 18,551. The 12 dissociation constants (KDs) for these drugs were 0-90 nM, 6&60 nM, and 55 nM respectively. These results are compared with those for other adrenergic agents, including timolol. The potential role of topical 12 blockers in glaucoma is discussed.