Physical Activity and Cardiorespiratory Fitness Are Beneficial for White Matter in Low-Fit Older Adults
Physical Activity and Cardiorespiratory Fitness Are Beneficial for White Matter in Low-Fit Older Adults
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DOI：
10.1371/journal.pone.0107413
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发表时间：
2014-09-17
期刊：
影响因子：
3.7
通讯作者：
Kramer, Arthur F.
中科院分区：
文献类型：
--
作者：
Burzynska, Agnieszka Zofia;Chaddock-Heyman, Laura;Kramer, Arthur F.
体力活动（PA）和心肺功能（CRF）与晚年更好的认知功能相关，但这些关系的神经相关性尚不清楚。为了研究这些相关性，我们在88名健康的低适应性成年人（年龄60-78岁）中检查了PA和CRF与白色物质（WM）完整性测量的相关性。使用加速度计，我们客观地测量了久坐行为，轻PA，中度到剧烈PA（MV-PA）超过一周。我们发现，更大的MV-PA与WM病变体积较小有关。PA和WM微结构完整性（用扩散张量成像测量）之间的关联是区域特异性的：轻PA与颞部WM相关，而久坐不动的行为与海马旁WM的较低完整性相关。我们的研究结果强调，参与各种强度的PA，同时避免久坐，对维持老年WM健康很重要，支持强调积极生活方式重要性的公共卫生建议。
Physical activity (PA) and cardiorespiratory fitness (CRF) are associated with better cognitive function in late life, but the neural correlates for these relationships are unclear. To study these correlates, we examined the association of both PA and CRF with measures of white matter (WM) integrity in 88 healthy low-fit adults (age 60-78). Using accelerometry, we objectively measured sedentary behavior, light PA, and moderate to vigorous PA (MV-PA) over a week. We showed that greater MV-PA was related to lower volume of WM lesions. The association between PA and WM microstructural integrity (measured with diffusion tensor imaging) was region-specific: light PA was related to temporal WM, while sedentary behavior was associated with lower integrity in the parahippocampal WM. Our findings highlight that engaging in PA of various intensity in parallel with avoiding sedentariness are important in maintaining WM health in older age, supporting public health recommendations that emphasize the importance of active lifestyle.