The patterns of melanosome distribution in keratinocytes of human skin as one determining factor of skin colour
The patterns of melanosome distribution in keratinocytes of human skin as one determining factor of skin colour
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DOI：
10.1046/j.1365-2133.2003.05473.x
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发表时间：
2003-09-01
影响因子：
10.3
通讯作者：
Boissy, RE
中科院分区：
文献类型：
--
作者：
Thong, HY;Jee, SH;Boissy, RE
皮肤颜色的决定因素之一是角质形成细胞内黑素体的分布模式。在白种人中，浅色皮肤的角质形成细胞中的黑素体以膜结合簇的形式分布，而在非洲人/美国人中，深色皮肤的角质形成细胞中的黑素体往往更大并且单独分布。已经表明黑色素含量，人表皮中黑色素的组成和黑色素体的大小随种族和长期日晒而有很大的不同。目的定量评估已转移到角质形成细胞中的黑色素体在受光保护的皮肤中的分布模式。（掌侧前臂）皮肤，并将这些数据与来自浅肤色高加索人和深肤色非洲人的数据进行比较。Americanindividuals.Methods电子显微镜used.Results我们已经证明，黑素体内角质形成细胞的亚洲皮肤分布作为一个单独的和集群的黑素体的比例为62.6%与37.4%，分别组合。这与深色和浅色皮肤角质形成细胞形成对比，其中黑素体分别主要是单个的（88.9%）和成簇的（84.5%）。平均+/- SD黑素小体大小的分析也揭示了大小随种族的进行性变化，深色皮肤中的黑色素体最大，（1.44 +/- 0.67 mum（2）x 10（-2）），其次是亚洲皮肤（1.36 +/- 0.15 mum（2）x 10（-2））和高加索人皮肤（0.94 +/- 0.48 mum（2）x 10（-2））。此外，它表明，单独分布的黑素体往往有一个更大的尺寸比集群melanosomes.Conclusions目前的数据表明，可能有一个大小梯度的黑素体，包括全球肤色着色和黑素体分布在角质形成细胞的亚洲皮肤之间的中间，在轻高加索和黑暗的非洲/美国皮肤。
Background One determining factor of skin colour is the distribution pattern of melanosomes within keratinocytes. Melanosomes in keratinocytes of light skin as in Caucasians are distributed as membrane-bound clusters, whereas the melanosomes in keratinocytes of dark skin as in African/American individuals tend to be larger and distributed individually. It has been shown that melanin content, melanin composition and the size of melanosomes in the human epidermis vary considerably with both ethnicity and chronic sun exposure.Objectives To assess quantitatively the distribution pattern of melanosomes that have been transferred to keratinocytes in the photoprotected ( volar forearm) skin from normal Asian individuals and to compare these data with those from light-skinned Caucasian and dark-skinned African / American individuals.Methods Electron microscopy was used.Results We have demonstrated that melanosomes within keratinocytes of Asian skin are distributed as a combination of individual and clustered melanosomes with a proportion of 62.6% vs. 37.4%, respectively. This contrasts with dark and light skin keratinocytes where melanosomes are predominantly individual (88.9%) and clustered (84.5%), respectively. Analysis of mean +/- SD melanosome size also revealed a progressive variation in size with ethnicity, melanosomes in dark skin being the largest (1.44 +/- 0.67 mum(2) x 10(-2)) followed in turn by those in Asian skin (1.36 +/- 0.15 mum(2) x 10(-2)) and Caucasian skin (0.94 +/- 0.48 mum(2) x 10(-2)). In addition, it was shown that the melanosomes that are individually distributed tend to have a larger size than the clustered melanosomes.Conclusions The present data indicate that there may be a size gradient of melanosomes encompassing the global complexion coloration and that the melanosome distribution in keratinocytes of Asian skin is intermediate between that in light Caucasian and dark African / American skin.