Use of anti-inflammatory and non-narcotic analgesic drugs and risk of non-Hodgkin's lymphoma (NHL) (United States)
Use of anti-inflammatory and non-narcotic analgesic drugs and risk of non-Hodgkin's lymphoma (NHL) (United States)
复制标题
DOI：
10.1023/a:1021953224822
复制
发表时间：
2002-12-01
影响因子：
2.3
通讯作者：
Watanabe, H
中科院分区：
文献类型：
--
作者：
Kato, I;Koenig, KL;Watanabe, H
目的：探讨接触抗炎药和非麻醉镇痛药是否与非霍奇金淋巴瘤 (NHL) 风险相关。方法：在纽约州北部的女性中进行了一项病例对照研究。该研究涉及通过纽约州癌症登记处确定的 376 例 NHL 病例以及从 Medicare 受益人档案和纽约州驾驶执照记录中随机选择的 463 名对照患者。有关过去 20 年常用药物使用情况和潜在混杂变量的信息是通过电话采访获得的。使用无条件逻辑回归模型估计比值比 (OR) 和 95% 置信区间 (CI)。 结果：曾经使用可的松注射剂和口服可的松相关的风险并未显着增加（注射可的松 OR = 1.44 (CI 0.98-2.11)，口服可的松 1.21 (CI 0.73-2.00)，尽管两者之间没有明确的剂量反应关系另一方面，NHL 的风险随着非甾体类抗炎药和非麻醉性镇痛药 (NSAID/NNAD) 的使用频率而逐渐增加（趋势 p 值为 0.008），与平均每月使用次数少于一次的女性相比，其 OR 为 1.90 (CI 1.01-3.57)。长期使用布洛芬最为明显，阿司匹林中等，对乙酰氨基酚最不明显。结论：由于与 NSAID/NNAD 使用相关的人群归因风险可能很大，因此我们的结果需要在进一步的流行病学研究中得到验证。
Objective: To examine whether exposures to anti-inflammatory and non-narcotic analgesic drugs are associated with risk of non-Hodgkin's lymphoma (NHL).Methods: A case-control study was conducted among women living in upstate New York. The study involved 376 cases of NHL identified through the New York State Cancer Registry and 463 controls randomly selected from the Medicare beneficiary files and New York State driver's license records. Information regarding use of common medications in the past 20 years and potential confounding variables was obtained by telephone interview. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using an unconditional logistic regression model.Results: There were non-significant increases in risk associated with ever use of cortisone injections and oral cortisone (OR = 1.44 (CI 0.98-2.11) for injections and 1.21 (CI 0.73-2.00) for oral cortisone, although there was no clear dose response relationship with either type. On the other hand, the risk of NHL progressively increased with the frequency of use of non-steroidal anti-inflammatory and non-narcotic analgesic drugs (NSAID/NNAD) (p-value for trend 0.008). Women who used any of these medications daily for more than 10 years had an OR of 1.90 (CI 1.01-3.57), compared with those who used it less than once a month on average. The risk associated with long-term use was most pronounced for ibuprofen, intermediate for aspirin, and least for acetaminophen.Conclusions: Because the population-attributable risk associated with NSAID/NNAD use is potentially large, our results need to be verified in further epidemiologic studies.