Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women
Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women
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DOI：
10.1017/s146114570400416x
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发表时间：
2004-06-01
影响因子：
4.8
通讯作者：
Deckert, J
中科院分区：
文献类型：
--
作者：
Domschke, K;Freitag, CM;Deckert, J
恐慌症是一种焦虑症，估计遗传力高达48％。药理学和遗传学研究表明，编码参与儿茶酚胺能系统的蛋白质的基因可能与该疾病的发病机理有关。在本研究中，我们在115例患有恐慌症和年龄和性别匹配的对照组的患者中，我们在Catechol-O-O-甲基转移酶（COMT）基因的编码区域中基因分型在Catechol-O-O-甲基转移酶（COMT）基因的编码区域中进行了基因分型。关联分析显示，恐慌症患者（p = 0.04），尤其是在女性患者（p = 0.01），但在男性患者中（p = 1.0），恐慌症患者（p = 0.04）的更活跃的COMT等位基因（4726 = V158）显着过多。在单胺氧化酶A启动子（MAOA-LPR）中，对COMT多态性的可能相互作用与先前报道的功能性30乘VNTR的可能相互作用评估没有产生显着结果。我们的数据支持472G/A（V158M）COMT多态性或附近恐慌症发病机构的作用。
Panic disorder is an anxiety disorder with an estimated heritability of up to 48%. Pharmacological and genetic studies suggest that genes coding for proteins involved in the catecholaminergic system might be relevant for the pathogenesis of the disease. In the present study, we genotyped a single nucleotide polymorphism (472G/A=V158M) in the coding region of the catechol-O-methyl-transferase (COMT) gene in 115 patients with panic disorder and age- and sex-matched controls. Association analysis revealed a significant excess of the more active COMT allele (4726 = V158) in patients with panic disorder (p=0.04), particularly in female patients (p=0.01), but not in male patients (p=1.0). The assessment of a possible interaction of the COMT polymorphism with a previously reported functional 30-by VNTR in the monoamine oxidase A promoter (MAOA-LPR) in female patients did not yield significant results. Our data support a role of the 472G/A (V158M) COMT polymorphism or a nearby locus in the pathogenesis of panic disorder in women.