The locus of motor activity in the superior colliculus of the rhesus monkey is unaltered during saccadic adaptation.
The locus of motor activity in the superior colliculus of the rhesus monkey is unaltered during saccadic adaptation.
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DOI：
10.1523/jneurosci.3111-10.2010
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发表时间：
2010-10-20
期刊：
影响因子：
--
通讯作者：
Freedman EG
中科院分区：
文献类型：
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作者：
Quessy S;Quinet J;Freedman EG
运动相关活动在上丘（SC）深层的位置被认为产生一个指定跳眼运动的幅度和方向的所需位移命令。然而，在扫视开始后，通过偷偷地移动目标位置，可以系统地改变视觉目标的扫视眼运动幅度。视目标是离注视位置更近还是更远，对扫视幅度的适应会导致运动比控制运动更小或更大。SC是否指定了到原始目标位置的所需运动，或者SC活动是否指定了随着适应进展而观察到的幅度改变运动的矢量，这仍然是一个悬而未决的问题。我们通过记录头部受限的恒河猴在向后和向前跳跃适应过程中SC中与扫视相关的突发神经元的活动来研究这个问题。在每个方向的适应过程中，我们没有发现与SC活动位点的变化相一致的证据，尽管眼跳振幅发生了变化；在向前或向后跳眼适应过程中，SC运动相关活动的位置似乎没有被“重新映射”。这些数据与提出SC在调节适应过程中观察到的扫视幅度变化中起关键作用的假设不一致。
The location of motor-related activity in the deeper layers of the superior colliculus (SC) is thought to generate a desired displacement command specifying the amplitude and direction of saccadic eye movements. However, the amplitude of saccadic eye movements made to visual targets can be systematically altered by surreptitiously moving the target location after the saccade has been initiated. Depending on whether the target is moved closer to or further from the fixation location, adaptation of saccade amplitude results in movements that are either smaller or larger than control movements. It remains an open question whether the SC specifies the desired movement to the original target location or whether SC activity specifies the vector of the amplitude-altered movement that is observed as adaptation progresses. We investigated this question by recording the activity of saccade related burst neurons in the SC of head restrained rhesus monkeys during both backward and forward saccadic adaptation. During adaptation in each direction, we find no evidence that is consistent with a change in the locus of SC activity despite changes in saccade amplitude; the location of SC motor-related activity does not appear to be ‘re-mapped’ during either forward or backward saccadic adaptation. These data are inconsistent with hypotheses that propose a key role for the SC in mediating the changes in saccade amplitude observed during adaptation.