PLACENTAL MALARIA .1. PATHOLOGICAL CLASSIFICATION
PLACENTAL MALARIA .1. PATHOLOGICAL CLASSIFICATION
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DOI：
10.1111/j.1365-2559.1993.tb00110.x
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发表时间：
1993-03-01
期刊：
影响因子：
6.4
通讯作者：
GREENWOOD, BM
中科院分区：
文献类型：
--
作者：
BULMER, JN;RASHEED, FN;GREENWOOD, BM
孕妇比非孕妇更容易感染疟疾。本研究的目的是开发一个简单的分类系统，适用于在现场条件下收集的胎盘胎盘疟疾感染的组织病理学诊断。根据寄生虫和疟疾色素的存在和分布，将胎盘分为四组：活动性感染、活动性慢性感染、慢性感染后感染和未感染。胎盘寄生虫病的发生率（26.4%）与流行病学研究中记录的胎盘寄生虫病的患病率一致。另外29.8%的胎盘仅在纤维蛋白中显示色素，表明慢性感染。慢性胎盘疟疾感染最常见于妊娠期疟疾，这可能反映了胎盘寄生虫的无效清除。感染类别之间的季节性波动支持胎盘感染的进展，并延迟色素从纤维蛋白中清除。拟议的分类系统允许由两名独立的观察员诊断不同类别的胎盘疟疾感染。一个标准化的诊断方法可以提高对妊娠期疟疾感染的胎盘病理学和出生体重下降的理解。
Pregnant women are more likely to contract malaria than their non-pregnant counterparts. The aim of this study was to develop a simple classification system for the histopathological diagnosis of placental malaria infection applicable to placentas collected in field conditions. The placentas were classified into four groups depending on the presence and distribution of parasites and malaria pigment: active infection, active-chronic infection, past-chronic infection, not infected. The frequency of parasitized placentas (26.4%) was in keeping with the prevalence of placental parasitaemia documented in epidemiological studies. An additional 29.8% placentas showed pigment in fibrin only, indicating past-chronic infection. Chronic placental malaria infection was most common in primigravidae, possibly reflecting ineffective clearance of parasites from the placenta. Seasonal fluctuations between infection categories support progression of placental infection with delayed clearance of pigment from fibrin. The proposed classification system has allowed diagnosis of different categories of placental malaria infection by two independent observers. A standardized method of diagnosis may enhance understanding of placental pathology and reduced birth weight in malaria infection during pregnancy.