CELLULAR INTERACTIONS WITH SYNTHETIC-POLYMER SURFACES IN CULTURE
CELLULAR INTERACTIONS WITH SYNTHETIC-POLYMER SURFACES IN CULTURE
复制标题
DOI：
10.1016/0142-9612(85)90100-0
复制
发表时间：
1985-01-01
期刊：
影响因子：
14
通讯作者：
TIGHE, BJ
中科院分区：
文献类型：
--
作者：
LYDON, MJ;MINETT, TW;TIGHE, BJ
合成聚合物作为生物材料的成功与否取决于它们的界面性质以及在体内与细胞和生物体液的相互作用。确定生物相容性要求的一个有用的实验方法是研究合成底物影响真核细胞培养行为的机制。在这里，我们提出了一系列合成聚合物的物理和化学底物性质与细胞行为之间的关系的概述。我们将我们的结果与体内组织相容性的理论联系起来。
The success of synthetic polymers as biomaterials depends upon their interfacial properties and resultant interactions with cells and biological fluids in vivo. A useful experimental approach to defining requirements for biocompatibility is to study the mechanisms by which synthetic substrata influence eukaryote cell behaviour in culture. Here we present an overview of the relationships between physical and chemical substratum properties and cell behaviour on a range of synthetic polymers. We relate our results to theories of in vivo tissue compatibility.