Interferon-activated signal transduction to the nucleus.
Interferon-activated signal transduction to the nucleus.
复制标题
DOI：
10.1016/0955-0674(94)90144-9
复制
发表时间：
1994-04
影响因子：
7.5
通讯作者：
Ke Shuai
中科院分区：
文献类型：
--
作者：
Ke Shuai
最近对干扰素基因激活的研究发现了从细胞表面干扰素受体到细胞核的直接信号传导途径。干扰素激活 JAK 酪氨酸激酶，通过直接酪氨酸磷酸化，激活称为 STAT（信号转导子和转录激活子）的潜在细胞质转录因子家族，然后转移到细胞核以指导转录激活。
Recent studies on gene activation by interferons have uncovered a direct signaling pathway from the cell-surface receptor for interferons to the nucleus. Activation of JAK tyrosine kinases by interferons leads to activation, by direct tyrosine phosphorylation, of a family of latent cytoplasmic transcription factors named STATs (for signal transducers and activators of transcription), which then translocate to the nucleus to direct transcriptional activation.