Dynamic role of hyaluronan (HYA) in connective tissue activation and inflammation
Dynamic role of hyaluronan (HYA) in connective tissue activation and inflammation
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DOI：
10.1046/j.1365-2796.1997.00173.x
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发表时间：
1997-07-01
影响因子：
11.1
通讯作者：
Hallgren, R
中科院分区：
文献类型：
--
作者：
Gerdin, B;Hallgren, R
在几种人类和实验性炎症条件下，HYA的组织积累增加。人类结节病、特发性肺纤维化和农民肺以及大鼠实验性博莱霉素诱导的肺损伤就是这种情况。人和大鼠的移植物排斥反应、小鼠的实验性心肌炎和大鼠的心肌梗死遵循相同的模式。在人类炎症性肠病的肠腔灌注液中也出现了增加量的HYA。在伤口愈合中可见HYA的短暂积累，这在胎儿中更持久。水的积累增加和炎症细胞上受体配体的呈递是HYA积累的两个结果。
An increased tissue accumulation of HYA occurs in several human and experimental inflammatory conditions. Such is the case in sarcoidosis, idiopathic pulmonary fibrosis and farmer's lung in man, and experimental bleomycin-induced lung damage in rats. Graft rejection in man and rats, experimental myocarditis in mice and myocardial infarction in rats follow the same pattern. Increased amounts of HYA also appear in gut luminal perfusion fluid in human inflammatory bowel disease. A transient accumulation of HYA is seen in wound healing, which is more sustained in fetuses. An increased accumulation of water and presentation of ligands for receptors on inflammatory cells are two consequences of the HYA accumulation.