The effect of counseling on willingness to use a hypothetical medication and perceptions of medication safety
The effect of counseling on willingness to use a hypothetical medication and perceptions of medication safety
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DOI：
10.1016/j.sapharm.2017.03.058
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发表时间：
2018-03-01
影响因子：
3.9
通讯作者：
Blalock, Susan J.
中科院分区：
文献类型：
--
作者：
Bitonti, Michael;Patel, Payal;Blalock, Susan J.
背景：药物依从性差是一个持续存在的问题，并导致住院和医疗费用增加。虽然大多数不良反应是罕见的，不良反应的感知风险可能会导致低adherence rates.Objectives：本研究的目的是确定如何不良反应的可能性和药剂师咨询的不良反应预防影响individuals '：（1）愿意使用一种假设的药物和（2）用药safety.Methods的看法：本研究采用了3 × 3的实验设计。参与者（n = 601）观看了一个假设的场景，要求他们想象被开了一种抗哮喘药物，可能会导致咽喉真菌感染。参与者被随机分配到9种不同的场景中的1种：发生感染的概率（5%，20%，没有提到概率）以及他们是否被告知如何降低感染风险（没有讨论预防策略，讨论预防策略，讨论预防策略并解释其如何工作）。结果：当真菌感染的概率为20%时，参与者不太愿意服用药物（F = 12.86，p < 0.0001），并且认为它不太安全（F = 13.11，p < 0.0001），而不是5%或没有给出概率信息时。参与者更愿意服用药物（F = 11.78，p < 0.0001），并认为当给予预防策略时更安全（F = 11.17，p < 0.0001）。最后，有一个非统计学显着的概率和预防策略信息之间的相互作用，这样的预防信息的提供减少了两个愿意使用的药物和感知的药物safety.Conclusions的感染概率的变化的影响：最佳的风险沟通涉及更多的告知患者可能的不良反应。药剂师可以潜在地提高患者对治疗建议的接受程度，并通过咨询患者可以实施的策略来减轻药物安全性问题，以降低不良反应的感知风险。(C)2017爱思唯尔公司All rights reserved.
Background: Poor medication adherence is an ongoing issue, and contributes to increased hospitalizations and healthcare costs. Although most adverse effects are rare, the perceived risk of adverse effects may contribute to low adherence rates.Objectives: The objective of this study was to determine how adverse effect likelihood and pharmacist counseling on adverse effect prevention affects individuals': (1) willingness to use a hypothetical medication and (2) perceptions of medication safety.Methods: This study used a 3 x 3 experimental design. Participants (n = 601) viewed a hypothetical scenario asking them to imagine being prescribed an anti-asthma medication that could cause fungal infections of the throat. Participants were randomized to 1 of 9 scenarios that differed on: probability of developing an infection (5%, 20%, no probability mentioned) and whether they were told how to reduce the risk of infection (no prevention strategy discussed, prevention strategy discussed, prevention strategy discussed with explanation for how it works). Participants were recruited through Amazon Mechanical Turk.Results: Participants were less willing to take the medication (F = 12.86, p < 0.0001) and considered it less safe (F = 13.11, p < 0.0001) when the probability of fungal infection was presented as 20% compared to 5% or when no probability information was given. Participants were more willing to take the medication (F = 11.78, p < 0.0001) and considered it safer (F = 11.17, p < 0.0001) when a prevention strategy was given. Finally, there was a non-statistically significant interaction between the probability and prevention strategy information such that provision of prevention information reduced the effect of variation in the probability of infection on both willingness to use the medication and perceived medication safety.Conclusions: Optimal risk communication involves more than informing patients about possible adverse effects. Pharmacists could potentially improve patient acceptance of therapeutic recommendations, and allay medication safety concerns, by counseling about strategies patients can implement to reduce the perceived risk of adverse effects. (C) 2017 Elsevier Inc. All rights reserved.