Effects of sarA inactivation on the intrinsic multidrug resistance mechanism of Staphylococcus aureus.
Effects of sarA inactivation on the intrinsic multidrug resistance mechanism of Staphylococcus aureus.
复制标题
sarA失活对金黄色葡萄球菌内在多药耐药机制的影响。
DOI：
10.1016/j.femsle.2004.06.047
复制
发表时间：
2004
影响因子：
2.1
通讯作者：
Gustafson,JohnE
中科院分区：
文献类型：
--
作者：
O'Leary,JessicaO;Langevin,MarkJ;Price,ChristopherTD;Blevins,JonS;Smeltzer,MarkS;Gustafson,JohnE
ThesarAlocus ofStaphylococccus aureusregulates the synthesis of over 100 genes on theS. aureuschromosome. We now report the effects ofsarAinactivation on intrinsic multidrug resistance expression byS. aureus. In a strain-dependent fashion,sarA::kanmutants of three unrelated strains ofS. aureusdemonstrated significantly increased susceptibility to five or more of the following substances: the antibiotics ciprofloxacin, fusidic acid, and vancomycin; the DNA-intercalating agent ethidium; and four common household cleaner formulations. In addition, all threesarA::kanmutants demonstrated significantly increased accumulation of ciprofloxacin and onesarA::kanmutant demonstrated increased ethidium accumulation. Our data therefore indicate thatsarAplays a role in the intrinsic multidrug resistance mechanism expressed byS. aureus, in part by regulating drug accumulation.
