Preparation and characterization of Boron carbide nanoparticles for use as a novel agent in T cell-guided boron neutron capture therapy
Preparation and characterization of Boron carbide nanoparticles for use as a novel agent in T cell-guided boron neutron capture therapy
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DOI：
10.1016/j.apradiso.2005.08.003
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发表时间：
2006-03-01
影响因子：
1.6
通讯作者：
Bjornholm, T
中科院分区：
文献类型：
--
作者：
Mortensen, MW;Sorensen, PG;Bjornholm, T
Boron carbide nanoparticles are proposed as a system for T cell-guided boron neutron capture therapy. Nanoparticles were produced by ball milling in various atmospheres of commercially available boron carbide. The physical and chemical properties of the particles were investigated using transmission electron microscopy, photon correlation spectroscopy, X-ray photoelectron spectroscopy, X-ray diffraction, vibrational spectroscopy, gel electrophoresis and chemical assays and reveal profound changes in surface chemistry and structural characteristics. In vitro thermal neutron irradiation of B16 melanoma cells incubated with sub-100 nm nanoparticles (381.5 mu g/g B-10) induces complete cell death. The nanoparticles alone induce no toxicity. (c) 2005 Elsevier Ltd. All rights reserved.
